4-[4-(3-Hydroxy-3-methylbutyl)sulfinylphenyl]sulfinyl-2-methylbutan-2-ol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-[4-(3-Hydroxy-3-methylbutyl)sulfinylphenyl]sulfinyl-2-methylbutan-2-ol
• 化学式: C₁₆H₂₆O₄S₂
• 分子量: 346.5
• InChiKey: DJJKVUMPLCRPEC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  22
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  113
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• SULFOXIDE AND BIS-SULFOXIDE COMPOUNDS AND COMPOSITIONS FOR CHOLESTEROL MANAGEMENT AND RELATED USES
  申请人：Esperion Therapeutics Inc.

  公开号：EP1366024A2

  公开（公告）日：2003-12-03
• US6673780B2
  申请人：——

  公开号：US6673780B2

  公开（公告）日：2004-01-06
• [EN] SULFOXIDE AND BIS-SULFOXIDE COMPOUNDS AND COMPOSITIONS FOR CHOLESTEROL MANAGEMENT AND RELATED USES<br/>[FR] COMPOSES DE SULFOXYDE ET DE BIS-SULFOXYDE ET COMPOSITIONS POUR REGULER LE CHOLESTEROL, ET APPLICATIONS ASSOCIEES
  申请人：ESPERION THERAPEUTICS INC

  公开号：WO2002030882A2

  公开（公告）日：2002-04-18

  The present invention relates to sulfoxide and bis-sulfoxide compounds of formula I, formula II, or formula III (in which the variables are as defined in the claims), compositions comprising sulphoxide and bissulphoxide compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a composition comprising an ether compound. The compounds, compositions, and methods of the invention are also useful for treating and preventing Alzheimer's Disease, Syndrome X, peroxisome proliferator activated receptor-related disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal disease, cancer inflammation, and impotence. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.