N-[2-(2-Fluorophenyl)ethyl]-2-[(pyridin-4-ylmethyl)amino](3-pyridyl)carboxamide | 453561-61-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: N-[2-(2-Fluorophenyl)ethyl]-2-[(pyridin-4-ylmethyl)amino](3-pyridyl)carboxamide
• 英文别名: N-[2-(2-fluorophenyl)ethyl]-2-(pyridin-4-ylmethylamino)pyridine-3-carboxamide
• CAS: 453561-61-0
• 化学式: C₂₀H₁₉FN₄O
• 分子量: 350.395
• InChiKey: VWCWMHZGPSRJEG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  26
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  66.9
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Substituted alkylamine derivatives and methods of use
  申请人：——

  公开号：US20030125339A1

  公开（公告）日：2003-07-03

  Selected heterocyclic compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

  选择的杂环化合物对预防和治疗疾病，如血管生成介导的疾病，具有有效性。该发明涵盖了新颖的化合物、类似物、前药和其药用可接受的衍生物，药物组合物以及预防和治疗涉及癌症等疾病和其他疾病或病况的方法。该发明还涉及制备此类化合物的过程以及在此类过程中有用的中间体。
• [EN] SUBSTITUTED ALKYLAMINE DERIVATIVES AND METHODS OF USE<br/>[FR] DERIVES D'ALKYLAMINE SUBSTITUES ET METHODES D'UTILISATION
  申请人：AMGEN INC

  公开号：WO2002066470A1

  公开（公告）日：2002-08-29

  Selected heterocyclic compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

  选定的杂环化合物对于预防和治疗由血管生成介导的疾病等疾病有效。本发明涵盖了新的化合物、类似物、前药和药学上可接受的衍生物、药物组成物以及预防和治疗癌症等疾病和其他疾病或病况的方法。该发明还涉及制备这种化合物的过程以及在这种过程中有用的中间体。
• SUBSTITUTED ALKYLAMINE DERIVATIVES AND METHODS OF USE
  申请人：CHEN Guoqing

  公开号：US20120065185A1

  公开（公告）日：2012-03-15

  Selected heterocyclic compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like.

  选择的杂环化合物对于预防和治疗疾病，如血管生成介导的疾病是有效的。该发明涵盖了新型化合物、类似物、前药和其药学上可接受的衍生物、药物组合物以及预防和治疗涉及癌症等疾病和其他疾病或病症的方法。
• US6878714B2
  申请人：——

  公开号：US6878714B2

  公开（公告）日：2005-04-12
• US6995162B2
  申请人：——

  公开号：US6995162B2

  公开（公告）日：2006-02-07