3-methyl-6-[5-(6-methylpyridin-2-yl)-1H-[1,2,3]triazol-4-yl]-[1,2,4]triazolo(4,3-a)pyridine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3-methyl-6-[5-(6-methylpyridin-2-yl)-1H-[1,2,3]triazol-4-yl]-[1,2,4]triazolo(4,3-a)pyridine
• 英文别名: 3-methyl-6-[5-(6-methylpyridin-2-yl)-2H-triazol-4-yl]-[1,2,4]triazolo[4,3-a]pyridine
• 化学式: C₁₅H₁₃N₇
• 分子量: 291.315
• InChiKey: PPLNCZOTWDLLLN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  84.6
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Novel triazole compounds as transforming growth factor (TGF) inhibitors
  申请人：Munchhof J. Michael

  公开号：US20060128761A1

  公开（公告）日：2006-06-15

  Novel triazole compounds, including derivatives thereof, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use are described. The compounds of the present invention are potent inhibitors of transforming growth factor (“TGF”)-β signaling pathway. They are useful in the treatment of various TGF-related disease states including, for example, cancer and fibrotic diseases.

  本发明涉及新型三唑化合物及其衍生物，以及制备它们的中间体，包括含有它们的制药组合物和它们的药用用途。本发明的化合物是转化生长因子（“TGF”）-β信号通路的有效抑制剂。它们在治疗各种TGF相关疾病状态方面非常有用，包括癌症和纤维化疾病。
• Novel triazole compounds as transforming growth factors (TGF) inhibitors
  申请人：Pfizer Inc

  公开号：US20040110798A1

  公开（公告）日：2004-06-10

  Novel triazole compounds, including derivatives thereof, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use are described. The compounds of the present invention are potent inhibitors of transforming growth factor (“TGF”)-&bgr; signaling pathway. They are useful in the treatment of various TGF-related disease states including, for example, cancer and fibrotic diseases.

  本发明描述了新型三唑类化合物，包括其衍生物、制备中间体、含有它们的制药组合物以及它们的药用。本发明的化合物是转化生长因子（“TGF”）-β信号通路的有效抑制剂。它们在治疗各种TGF相关疾病状态中非常有用，包括癌症和纤维化疾病等。
• EFFICIENT INDUCTION OF PLURIPOTENT STEM CELLS USING SMALL MOLECULE COMPOUNDS
  申请人：Ichida Justin

  公开号：US20120021519A1

  公开（公告）日：2012-01-26

  The disclosure features a method of producing a reprogrammed cell (e.g. an induced pluripotent stem cell or an undifferentiated cell) from a differentiated (e.g. somatic) cell. In some embodiments, the methods includes contacting a differentiated (e.g. somatic cell) with a TGFBR1 inhibitor or anti-TGF-β-antibody to produce a reprogrammed cell (e.g. pluripotent stem cell or undifferentiated cell). Embodiments of the present invention relate to a reprogrammed cell and methods and compositions for producing a chemically produced reprogrammed cell or populations thereof.
• US7053095B2
  申请人：——

  公开号：US7053095B2

  公开（公告）日：2006-05-30
• [EN] EFFICIENT INDUCTION OF PLURIPOTENT STEM CELLS USING SMALL MOLECULE COMPOUNDS<br/>[FR] INDUCTION EFFICACE DE CELLULES SOUCHES PLURIPOTENTES AU MOYEN DE COMPOSÉS À PETITE MOLÉCULE
  申请人：HARVARD COLLEGE

  公开号：WO2010033906A2

  公开（公告）日：2010-03-25

  The disclosure features a method of producing a reprogrammed cell (e.g. an induced pluripotent stem cell or an undifferentiated cell) from a differentiated (e.g. somatic) cell. In some embodiments, the methods includes contacting a differentiated (e.g. somatic cell) with a TGFBR1 inhibitor or anti-TGF-β-antibody to produce a reprogrammed cell (e.g. pluripotent stem cell or undifferentiated cell). Embodiments of the present invention relate to a reprogrammed cell and methods and compositions for producing a chemically produced reprogrammed cell or populations thereof.