(7,8-dihydro-2,6,9-trioxa-3-aza-cyclopenta[a]naphthalen-8-ylmethyl)-(4-phenyl-butyl)-amine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (7,8-dihydro-2,6,9-trioxa-3-aza-cyclopenta[a]naphthalen-8-ylmethyl)-(4-phenyl-butyl)-amine
• 英文别名: N-(2,3-dihydro-[1,4]dioxino[2,3-e][2,1]benzoxazol-2-ylmethyl)-4-phenylbutan-1-amine
• 化学式: C₂₀H₂₂N₂O₃
• 分子量: 338.406
• InChiKey: PMYNXDOBDJSBFP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  25
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  56.5
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Antipsychotic aminomethyl derivatives of 7,8-dihydro-2,6,9-trioxa-3-aza-cyclopenta[a]naphthalene
  申请人：Wyeth

  公开号：US20020198217A1

  公开（公告）日：2002-12-26

  Compounds of the formula: 1 useful for treatment of disorders such as schizophrenia, schizoaffective disorder, bipolar disorder, Parkinson's disease, L-DOPA induced pychoses and dyskinesias, Tourette's syndrome and hyperprolactinemia and in the treatment of drug addiction such as the addiction to ethanol, nicotine or cocaine and related illnesses.

  公式为1的化合物，可用于治疗精神分裂症、情感性精神障碍、双相情感障碍、帕金森病、L-DOPA诱发的精神病和运动障碍、抽动症、高泌乳素血症以及药物成瘾，如对乙酰醇、尼古丁或可卡因成瘾及相关疾病的治疗。
• US6800642B2
  申请人：——

  公开号：US6800642B2

  公开（公告）日：2004-10-05
• [EN] ANTIPSYCHOTIC AMINOMETHYL DERIVATIVES OF 7,8-DIHYDRO-2,6,9-TRIOXA-3-AZA-CYCLOPENTA[a]NAPHTHALENE<br/>[FR] DERIVES AMINOMETHYLES ANTIPSYCHOTIQUES DE 7,8-DIHYDRO-2,6,9-TRIOXA-3-AZA-CYCLOPENTA[A]NAPHTALENE
  申请人：WYETH CORP

  公开号：WO2002088141A2

  公开（公告）日：2002-11-07

  Coumpounds of the formula (I), useful for treatment of disorders such as schizophrenia, schizoaffective disorder, bipolar disorder, Parkinson?s disease, L-DOPA induced pychoses and dyskinsias, Tourette's syndrome and hyperprolactinemia and in the treatment of drug addiction such as the addition to ethanol, nicotine or cocaine and related illnesses.