1-[(Z)-octadec-9-enyl]azepan-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酰胺类
• 英文名称: 1-[(Z)-octadec-9-enyl]azepan-2-one
• 化学式: C₂₄H₄₅NO
• 分子量: 363.6
• InChiKey: RAGAJCBPQFVUJU-KTKRTIGZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.4
• 重原子数：
  26
• 可旋转键数：
  16
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• Pharmaceutical compositions containing 1-oleylazacycloheptan-2-one as enhancing agent of transport across biological membranes
  申请人：SCHWARZ PHARMA AG

  公开号：EP0552504A1

  公开（公告）日：1993-07-28

  The invention relates to pharmaceutical compositions for topical application containing at least one physiologically active agent and an effective amount of 1-oleylazacycloheptan-2-one as the human or animal epithelial membrane permeability enhancer, to the application of such pharmaceutical compositions by means of locally contacting the skin or other membrane of the human or animal with the above composition and to the 1-oleylazacycloheptan-2-one compound per se.

  本发明涉及用于局部应用的药物组合物，其中至少含有一种生理活性剂和有效量的 1-oleylazacycloheptan-2-one 作为人或动物上皮膜渗透性增强剂；涉及通过将上述组合物局部接触人或动物的皮肤或其他膜来应用此类药物组合物；还涉及 1-oleylazacycloheptan-2-one 化合物本身。
• Parenteral formulations of dopamine agonists
  申请人：VeroScience LLC

  公开号：EP2316423A1

  公开（公告）日：2011-05-04

  This invention relates to stable pharmaceutical compositions for parenteral administration comprising dopamine agonists and peripheral acting agents useful for treatment of metabolic disorders or key elements thereof. The parenteral dosage forms exhibit long stable shelf life and distinct pharmacokinetics.

  本发明涉及用于肠外给药的稳定药物组合物，其中包含多巴胺激动剂和外周作用剂，可用于治疗代谢紊乱或其关键因素。这种肠外剂型具有较长的稳定保质期和独特的药代动力学。
• Apparatus for teeth cleaning and oral delivery of an agent and method of using the same
  申请人：——

  公开号：US20030075731A1

  公开（公告）日：2003-04-24

  A mouthpad for cleaning teeth and oral transmucosal drug delivery has a U-shaped plate sized to cover substantially only the biting surfaces of upper and lower teeth of a human jaw. The plate is positioned between the upper teeth and lower teeth such that when the teeth are rinsed with a liquid, the liquid flows primarily through the crevices between individual teeth and physically detaches the adhering residue within. Alternatively, using fluids containing drugs for rinsing while biting on the plate can deliver drugs through the oral mucosa. A method of cleaning teeth and delivering drugs through oral mucosa using a plate positioned between the upper and lower teeth is also disclosed.

  一种用于清洁牙齿和口腔黏膜给药的咀嚼片有一个 U 形板，其大小基本上只能覆盖人下颌上牙和下牙的咬合面。该板位于上牙和下牙之间，这样，当用液体冲洗牙齿时，液体主要流经各个牙齿之间的缝隙，并从物理上剥离其中粘附的残留物。另外，使用含有药物的液体漱口，同时咬住牙板，也可以通过口腔黏膜输送药物。此外，还公开了一种使用位于上下牙齿之间的牙板清洁牙齿并通过口腔黏膜输送药物的方法。
• PARENTERAL FORMULATIONS OF DOPAMINE AGONISTS
  申请人：VeroScience LLC

  公开号：EP2252259A2

  公开（公告）日：2010-11-24
• IMPROVED BROMOCRIPTINE FORMULATIONS
  申请人：VeroScience LLC

  公开号：EP3697418A1

  公开（公告）日：2020-08-26