N,4-dimethyl-N-[3-(4-methylpiperidin-1-yl)cyclopentyl]benzenesulfonamide;hydrochloride

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,4-dimethyl-N-[3-(4-methylpiperidin-1-yl)cyclopentyl]benzenesulfonamide;hydrochloride
• 化学式: C19H31ClN2O2S
• 分子量: 387.0
• InChiKey: OUDCIMMIPPQZJY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.69
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  49
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• 5-ht7 receptor antagonists
  申请人：Curtis Roy Neil

  公开号：US20050080077A1

  公开（公告）日：2005-04-14

  Substituted carbocyclic sulphonamide derivatives of formula (I), in which n is 0 or 1 and the other variables are as defined in the clains, are selective 5-HT 7 receptor antagonists and are thereby effective in the treatment of a variety of neurological conditions, including depression and sleep disorders.

  式(I)中的取代的环烷基磺酰胺衍生物，其中n为0或1，其他变量如声明中所定义，是选择性5-HT7受体拮抗剂，因此在治疗各种神经疾病，包括抑郁症和睡眠障碍方面有效。
• US7276607B2
  申请人：——

  公开号：US7276607B2

  公开（公告）日：2007-10-02
• [EN] 5-HT7 RECEPTOR ANTAGONISTS<br/>[FR] ANTAGONISTES DE RECEPTEUR 5-HT7
  申请人：MERCK SHARP & DOHME

  公开号：WO2003048118A1

  公开（公告）日：2003-06-12

  Substituted carbocyclic sulphonamide derivatives of formula (I), in which n is 0 or 1 and the other variables are as defined in the clains, are selective 5-HT7 receptor antagonists and are thereby effective in the treatment of a variety of neurological conditions, including depression and sleep disorders.