tert-butyl N-[3-methyl-1-oxo-1-[5-(2-phenylpropan-2-yl)-1,3,4-oxadiazol-2-yl]butan-2-yl]carbamate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: tert-butyl N-[3-methyl-1-oxo-1-[5-(2-phenylpropan-2-yl)-1,3,4-oxadiazol-2-yl]butan-2-yl]carbamate
• 化学式: C₂₁H₂₉N₃O₄
• 分子量: 387.5
• InChiKey: CAKSLWOUQGQWOH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  28
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  94.3
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• 1,3,4-Oxadiazole derivatives and process for producing the same
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：US20030153758A1

  公开（公告）日：2003-08-14

  Oxadiazole derivatives represented by formula (I): 1 (wherein R 1 represents a hydrogen atom or an amino-protective group; R 2 , R 3 , and R 4 each independently represents an alkyl group, a cycloalkyl group, a phenyl group which may be substituted, or a 3,4-methylenedioxyphenyl group, or R 3 and R 4 are taken together to represent a C 2-6 alkylene group), a process of producing the same, and a process for producing oxadiazole derivatives represented by formula (II): 2 (wherein all symbols have the same meanings as described above) using the above derivative. According to the invention, the compound represented by formula (II) is produced through fewer steps in a high yield.

  公式（I）表示的Oxadiazole衍生物：1（其中R1表示氢原子或氨基保护基；R2、R3和R4各自独立地表示烷基、环烷基、苯基（可能被取代）或3,4-亚甲二氧基苯基，或R3和R4一起表示C2-6烷基），制备该化合物的过程以及使用上述衍生物制备公式（II）表示的Oxadiazole衍生物的过程：2（其中所有符号的含义与上述相同）。根据本发明，在高收率下通过较少的步骤制备出公式（II）表示的化合物。
• 1,3,4-OXADIAZOLE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：EP1162199A1

  公开（公告）日：2001-12-12

  Oxadiazole derivatives represented by formula (I): (wherein R1 represents a hydrogen atom or an amino-protective group; R2, R3, and R4 each independently represents an alkyl group, a cycloalkyl group, a phenyl group which may be substituted, or a 3,4-methylenedioxyphenyl group, or R3 and R4 are taken together to represent a C2-6 alkylene group), a process of producing the same, and a process for producing oxadiazole derivatives represented by formula (II): (wherein all symbols have the same meanings as described above) using the above derivative. According to the invention, the compound represented by formula (II) is produced through fewer steps in a high yield.

  式 (I) 所代表的噁二唑衍生物： (其中R1代表氢原子或氨基保护基；R2、R3和R4各自独立地代表烷基、环烷基、可被取代的苯基或3，4-亚甲基二氧苯基，或R3和R4合起来代表C2-6亚烷基）的噁二唑衍生物，以及利用上述衍生物生产由式（II）代表的噁二唑衍生物的工艺： (其中所有符号的含义与上述相同）使用上述衍生物的工艺。 根据本发明，式（II）代表的化合物的生产步骤较少，产率较高。
• US6534658B1
  申请人：——

  公开号：US6534658B1

  公开（公告）日：2003-03-18