4-[(3-acetamidophenyl)-[1-(thiophen-2-ylmethyl)piperidin-4-ylidene]methyl]-N,N-diethylbenzamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-[(3-acetamidophenyl)-[1-(thiophen-2-ylmethyl)piperidin-4-ylidene]methyl]-N,N-diethylbenzamide
• 化学式: C₃₀H₃₅N₃O₂S
• 分子量: 501.7
• InChiKey: YAZKAXXYJYZBNR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  36
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  80.9
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
  申请人：Brown William

  公开号：US20060154964A1

  公开（公告）日：2006-07-13

  Compounds of general formula: (formula I) wherein R 1 , R 2 , R 3 , R 4 , and R 5 are as defined in the specification, as well as salts, enantiomers thereof and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.

  通式为（公式I）的化合物，其中R1、R2、R3、R4和R5如规范中所定义，以及其盐、对映体和包括这些化合物的药物组合物被制备出来。它们在治疗中有用，特别是在疼痛管理方面。
• DIARYLMETHYLIDENE PIPERIDINE DERIVATIVES, PREPARATIONS THEREOF AND USES THEREOF
  申请人：AstraZeneca AB

  公开号：EP1587790A2

  公开（公告）日：2005-10-26
• [EN] DIARYLMETHYLIDENE PIPERIDINE DERIVATIVES, PREPARATIONS THEREOF AND USES THEREOF<br/>[FR] DERIVES DE DIARYLMETHYLIDENE PIPERIDINE, PREPARATIONS ET UTILISATIONS DE CEUX-CI
  申请人：ASTRAZENECA AB

  公开号：WO2004062562A2

  公开（公告）日：2004-07-29

  Compounds of general formula (I): wherein R1, R2, R3, R4, and R5 are as defined in the specification, as well as salts, enantiomers thereof and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.