2-(5-Benzo[1,3]dioxol-5-yl-1H-imidazol-4-yl)-pyridine | 428816-34-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并间二氧杂环戊烯类
• 英文名称: 2-(5-Benzo[1,3]dioxol-5-yl-1H-imidazol-4-yl)-pyridine
• 英文别名: 2-[4-(1,3-benzodioxol-5-yl)-1H-imidazol-5-yl]pyridine
• CAS: 428816-34-6
• 化学式: C₁₅H₁₁N₃O₂
• 分子量: 265.271
• InChiKey: UNUJOWFCCIDCLO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  60
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Compounds
  申请人：——

  公开号：US20040039198A1

  公开（公告）日：2004-02-26

  This invention relates to 2-pyridyl substituted diarylimidazoles which are inhibitors of the transforming growth factor, (“TGF”)-&bgr; signaling pathway, in particular, the phosphorylation of smad2 or smad3 by the type I or activin-like kinase (“ALK”)-5 receptor, methods for their preparation and their use in medicine.

  本发明涉及2-吡啶基取代的二芳基咪唑，它们是转化生长因子（“TGF”）-β信号通路的抑制剂，特别是通过I型或类活素激酶（“ALK”）-5受体对smad2或smad3的磷酸化，它们的制备方法及其在医学上的应用。
• COMPOUNDS
  申请人：SMITHKLINE BEECHAM CORPORATION

  公开号：EP1349851A1

  公开（公告）日：2003-10-08
• EP1349851A4
  申请人：——

  公开号：EP1349851A4

  公开（公告）日：2004-09-08
• [EN] COMPOUNDS<br/>[FR] COMPOSES
  申请人：SMITHKLINE BEECHAM CORP

  公开号：WO2002040468A1

  公开（公告）日：2002-05-23

  2-Pyridyl substituted diarylimidazoles of formula (I) (I)wherein R1 is phenyl or naphthyl optionally substituted with one or more substituents selected from halo, C1-6alkoxy, C1-6alkylthio, C1-6alkyl, C1-6haloalkyl, -O-(CH2)m-Ph, -S-(CH2)m-Ph, cyano, phenyl, and CO2R, wherein R is hydrogen or C1-6alkyl and m is 0-3; or phenyl fused with a 5- to 7-membered aromatic or non-aromatic ring wherein said ring contains up to three heteroatoms, independently selected from N, O and S; R2, R3, R4 and R5 independently represent hydrogen, C1-6alkyl, C1-6alkoxy, C1-6haloalkyl, halo, NH2, NH-C1-6alkyl or NH(CH2)n-Ph wherein n is 0-3; or an adjacent pair of R2, R3, R4 and R5 form a fused 6-membered aromatic ring optionally containing up to 2 nitrogen atoms, said ring being optionally substituted by one or more substituents independently selected from C1-6alkyl, C1-6alkoxy, C1-6haloalkyl, halo, NH2, NH-C1-6alkyl or NH(CH2)n-Ph wherein n is 0-3, and the remainder of R2, R3, R4 and R5 represent hydrogen, C1-6alkyl, C1-6alkoxy, C1-6haloalkyl, halo, NH2, NH-C1-6alkyl or NH(CH2)n-Ph wherein n is 0-3; and one of X1 and X2 is N and the other is NR6, wherein R6 is hydrogen or C1-6alkyland salts and solvates thereof, are disclosed, as are methods for their preparation, pharmaceutical compositions containing them and their use in medicine.
• [EN] SMALL MOLECULES FOR ISLET EXPANSION<br/>[FR] PETITES MOLÉCULES POUR EXPANSION DES ÎLOTS
  申请人：UNIV CALIFORNIA

  公开号：WO2013119518A1

  公开（公告）日：2013-08-15

  Disclosed herein are methods and compounds for inducing the proliferation of and/or increasing the number of pancreatic cells, e.g., beta cells, in vitro, ex vivo, and in vivo. The methods and compounds may be used to expand a sample of pancreatic cells, e.g., beta cells, for downstream experiments or therapies.