(4Z)-4-(furan-2-ylmethylidene)-1-(4-phenylphenyl)pyrazolidine-3,5-dione

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (4Z)-4-(furan-2-ylmethylidene)-1-(4-phenylphenyl)pyrazolidine-3,5-dione
• 化学式: C₂₀H₁₄N₂O₃
• 分子量: 330.3
• InChiKey: DJWCAICSRWEADS-AQTBWJFISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  62.6
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Alkylidene pyrazolidinedione derivatives
  申请人：——

  公开号：US20040220188A1

  公开（公告）日：2004-11-04

  The present invention is related to the use of alkylidene pyrazolidinedione derivatives of formula (I) for the treatment and/or prevention of diabetes type I and/or II, impaired glucose tolerance, insulin resistance, hyperglycemia, obesity and polycystic ovary syndrome (PCOS). In particular, the present invention is related to the use of alkylidene pyrazolidinedione derivatives of formula (I) to modulate, notably to inhibit the activity of PTPs, in particular PTP1B, TC-PTP, SHP and GLEPP-1. The present invention is furthermore related to novel alkylidene pyrazolidinedione derivatives. (I) R1 and R2 represent independently from each other an unsubstituted or substituted aryl or heteroaryl. 1

  本发明涉及使用式(I)的烷基亚甲基吡唑啉二酮衍生物治疗和/或预防糖尿病I型和/或II型、糖耐量受损、胰岛素抵抗、高血糖、肥胖症和多囊卵巢综合症（PCOS）。特别是，本发明涉及使用式(I)的烷基亚甲基吡唑啉二酮衍生物调节，特别是抑制PTPs的活性，尤其是PTP1B、TC-PTP、SHP和GLEPP-1的活性。本发明还涉及新的烷基亚甲基吡唑啉二酮衍生物。(I)中，R1和R2各自独立地表示未取代或取代的芳基或杂环芳基。
• ALKYLIDENE PIRAZOLIDINEDIONE DERIVATIVES AND THEIR USE FOR TREATING DIABETES AND OBESITY
  申请人：Applied Research Systems ARS Holding N.V.

  公开号：EP1399156A2

  公开（公告）日：2004-03-24
• SMALL-MOLECULE INHIBITORS TARGETING G-PROTEIN-COUPLED RHO GUANINE NUCLEOTIDE EXCHANGE FACTORS
  申请人：CHILDREN'S HOSPITAL MEDICAL CENTER

  公开号：US20160083353A1

  公开（公告）日：2016-03-24

  Provided are inhibitors of Rho GTPase activation, and, in particular, compounds that inhibit RhoA activation by an RhoGEF. Also provided are related pharmaceutical compositions and methods. Also provided are methods of inhibiting Rho GTPase activation. Also provided are methods of screening for compounds that inhibit Rho GTPase activation by a RhoGEF.
• SMALL- MOLECULE INHIBITORS TARGETING G-PROTEIN-COUPLED RHO GUANINE NUCLEOTIDE EXCHANGE FACTORS
  申请人：Children's Hospital Medical Center

  公开号：US20170349553A1

  公开（公告）日：2017-12-07

  Provided are inhibitors of Rho GTPase activation, and, in particular, compounds that inhibit RhoA activation by an RhoGEF. Also provided are related pharmaceutical compositions and methods. Also provided are methods of inhibiting Rho GTPase activation. Also provided are methods of screening for compounds that inhibit Rho GTPase activation by a RhoGEF.
• US9951024B2
  申请人：——

  公开号：US9951024B2

  公开（公告）日：2018-04-24