(R)-3-((R)-3-methoxyquinuclidin-3-yl)-1-phenyl-1-(pyridin-3-yl)prop-2-yn-1-ol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 奎宁环
• 英文名称: (R)-3-((R)-3-methoxyquinuclidin-3-yl)-1-phenyl-1-(pyridin-3-yl)prop-2-yn-1-ol
• 英文别名: (1S)-3-[(3R)-3-methoxy-1-azabicyclo[2.2.2]octan-3-yl]-1-phenyl-1-pyridin-3-ylprop-2-yn-1-ol
• 化学式: C₂₂H₂₄N₂O₂
• 分子量: 348.445
• InChiKey: ZGBSEJYQXDWFRF-FGZHOGPDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  45.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  (3R)-3-ethynyl-1-azabicyclo[2.2.2]oct-3-yl methyl ether 、 3-苯甲酰基吡啶 在 正丁基锂 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 0.17h， 生成 (S)-3-((R)-3-methoxyquinuclidin-3-yl)-1-phenyl-1-(pyridin-3-yl)prop-2-yn-1-ol 、 (R)-3-((R)-3-methoxyquinuclidin-3-yl)-1-phenyl-1-(pyridin-3-yl)prop-2-yn-1-ol
  参考文献：
  名称：

  Potent anti-muscarinic activity in a novel series of quinuclidine derivatives

  摘要：

  The synthesis and biological evaluation of a novel family of M-3 muscarinic antagonists are described. A systematic modification of the substituents to a novel alkyne-quinuclidine scaffold yielded original compounds displaying potent in vitro anticholinergic properties. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.09.079

文献信息

• Potent anti-muscarinic activity in a novel series of quinuclidine derivatives
  作者：Jean-Philippe Starck、Patrice Talaga、Luc Quéré、Philippe Collart、Bernard Christophe、Patrick Lo Brutto、Sophie Jadot、Dinesh Chimmanamada、Matteo Zanda、Alain Wagner、Charles Mioskowski、Roy Massingham、Michel Guyaux

  DOI：10.1016/j.bmcl.2005.09.079

  日期：2006.1

  The synthesis and biological evaluation of a novel family of M-3 muscarinic antagonists are described. A systematic modification of the substituents to a novel alkyne-quinuclidine scaffold yielded original compounds displaying potent in vitro anticholinergic properties. (c) 2005 Elsevier Ltd. All rights reserved.