4-[[3-[(5-chlorothiophen-2-yl)methylsulfanyl]-1H-1,2,4-triazol-5-yl]methyl]-N,N-dimethylaniline

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 4-[[3-[(5-chlorothiophen-2-yl)methylsulfanyl]-1H-1,2,4-triazol-5-yl]methyl]-N,N-dimethylaniline
• 化学式: C₁₆H₁₇ClN₄S₂
• 分子量: 364.9
• InChiKey: MNFOXTSPTVHRLW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  98.4
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Compounds and methods
  申请人：Marino P. Joseph

  公开号：US20060247280A1

  公开（公告）日：2006-11-02

  Compounds of this invention are non-peptide, reversible inhibitors of type 2 methionine aminopeptidase, useful in treating conditions mediated by angiogenesis, such as cancer, haemangioma, proliferative retinopathy, rheumatoid arthritis, atherosclerotic neovascularization, psoriasis, ocular neovascularization and obesity.

  本发明的化合物是非肽类、可逆抑制剂，能用于治疗由血管生成介导的疾病，如癌症、血管瘤、增生性视网膜病变、类风湿性关节炎、动脉粥样硬化性新生血管、牛皮癣、眼部新生血管和肥胖症。
• COMPOUNDS AND METHODS
  申请人：SmithKline Beecham Corporation

  公开号：EP1379240A1

  公开（公告）日：2004-01-14
• EP1379240A4
  申请人：——

  公开号：EP1379240A4

  公开（公告）日：2009-04-08
• [EN] COMPOUNDS AND METHODS<br/>[FR] COMPOSES ET METHODES
  申请人：SMITHKLINE BEECHAM CORP

  公开号：WO2002078696A1

  公开（公告）日：2002-10-10

  Compounds of this invention are non-peptide, reversible inhibitors of type (2) methionine aminopeptidase, useful in treating conditions mediated by angiogenesis, such as cancer, haemangioma proliferative retinopathy, rheumatoid arthritis, atherosclerotic neovascularization, psoriasis, ocular neovascularization and obesity.