N-(6-Amino-hexyl)-2-(4-oxo-2-phenethyl-6-phenyl-4H-quinazolin-3-yl)-acetamide; hydrochloride

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: N-(6-Amino-hexyl)-2-(4-oxo-2-phenethyl-6-phenyl-4H-quinazolin-3-yl)-acetamide; hydrochloride
• 英文别名: N-(6-aminohexyl)-2-[4-oxo-6-phenyl-2-(2-phenylethyl)quinazolin-3-yl]acetamide
• 化学式: C₃₀H₃₄N₄O₂
• 分子量: 482.626
• InChiKey: MBUQCDCEVXUSQQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  36
• 可旋转键数：
  12
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  87.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  N-Boc-1,6-己二胺 在 N-甲基吗啉 、 盐酸 、 四(三苯基膦)钯 、 sodium carbonate 、 1-羟基苯并三唑 、 1-(3-二甲基氨基丙基)-3-乙基碳二亚胺 作用下， 生成 N-(6-Amino-hexyl)-2-(4-oxo-2-phenethyl-6-phenyl-4H-quinazolin-3-yl)-acetamide; hydrochloride
  参考文献：
  名称：

  Modeling directed design and biological evaluation of quinazolinones as non-peptidic growth hormone secretagogues

  摘要：

  Quinazolinone derivatives were synthesized and evaluated as non-peptidic growth hormone secretagogues. Modeling guided design of quinazolinone compound 21 led to a potency enhancement of greater than 200-fold compared to human growth hormone secretagogue affinity of a screening lead 4. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00584-3

文献信息

• METHODS OF TREATING TRAUMATIC BRAIN INJURY
  申请人：Oxeia Biopharmaceuticals Inc.

  公开号：EP3197482A1

  公开（公告）日：2017-08-02
• METHODS OF TREATING NEURODEGENERATIVE CONDITIONS
  申请人：Oxeia Biopharmaceuticals, Inc.

  公开号：US20170121385A1

  公开（公告）日：2017-05-04

  The present disclosure provides methods for treating a neurodegenerative condition or situation in a subject in need thereof, comprising administering to the subject an effective amount of a compound comprising ghrelin or a ghrelin variant.
• METHODS OF TREATING MILD BRAIN INJURY
  申请人：OXEIA BIOPHARMACEUTICALS, INC.

  公开号：US20170281732A1

  公开（公告）日：2017-10-05

  The present disclosure provides methods for treating mild brain injury and other neurological disorders in a subject in need thereof, comprising administering to the subject an effective amount of a compound comprising a ghrelin or ghrelin variant. This invention provides for methods for treating a mild brain injury or concussion in a patient wherein said method comprises administering to the subject in need thereof suffering from said mild brain injury or concussion an effective amount of a ghrelin variant or a composition comprising a ghrelin variant so as to treat said mild brain injury or concussion.
• US6849597B2
  申请人：——

  公开号：US6849597B2

  公开（公告）日：2005-02-01
• [EN] METHODS OF TREATING TRAUMATIC BRAIN INJURY<br/>[FR] PROCÉDÉS DE TRAITEMENT DE LÉSION CÉRÉBRALE TRAUMATIQUE
  申请人：OXEIA BIOPHARMACEUTICALS INC

  公开号：WO2016048488A1

  公开（公告）日：2016-03-31

  The present disclosure provides methods for treating traumatic brain injury and other neurological disorders in a subject in need thereof, comprising administering to the subject an effective amount of a composition comprising ghrelin or a ghrelin variant. This invention provides for methods for treating a severe or moderate traumatic brain injury in a patient wherein said method comprises administering to the subject suffering from said severe or moderate traumatic brain injury a therapeutic effective amount of ghrelin or a ghrelin variant or a composition comprising ghrelin or a ghrelin variant so as to treat said severe or moderate traumatic brain injury.