(2S)-3-[[7-phenylmethoxycarbonyl-8-[(pyridin-2-ylamino)methyl]-1-oxa-2,7-diazaspiro[4.4]non-2-ene-3-carbonyl]amino]-2-[(2,4,6-trimethylphenyl)sulfonylamino]propanoic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2S)-3-[[7-phenylmethoxycarbonyl-8-[(pyridin-2-ylamino)methyl]-1-oxa-2,7-diazaspiro[4.4]non-2-ene-3-carbonyl]amino]-2-[(2,4,6-trimethylphenyl)sulfonylamino]propanoic acid
• 化学式: C₃₃H₃₈N₆O₈S
• 分子量: 678.8
• InChiKey: IBXMYCNAAVLIET-FTGMFABGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  48
• 可旋转键数：
  13
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  197
• 氢给体数：
  4
• 氢受体数：
  12

文献信息

• Photoreceptors and photoreceptor progenitors produced from pluripotent stem cells
  申请人：Astellas Institute for Regenerative Medicine

  公开号：US11241460B2

  公开（公告）日：2022-02-08

  Methods are provided for the production of photoreceptor cells and photoreceptor progenitor cells from pluripotent stem cells. Additionally provided are compositions of photoreceptor cells and photoreceptor cells, as well as methods for the therapeutic use thereof. Exemplary methods may produce substantially pure cultures of photoreceptor cells and/or photoreceptor cells.

  提供了利用多能干细胞生产感光细胞和感光祖细胞的方法。此外，还提供了感光细胞和感光细胞的组合物及其治疗使用方法。示例方法可产生基本纯净的感光细胞和/或感光细胞培养物。
• PHARMACEUTICAL PREPARATIONS OF HUMAN RPE CELLS AND USES THEREOF
  申请人：Astellas Institute for Regenerative Medicine

  公开号：EP2780022B1

  公开（公告）日：2019-06-05
• COMBINATION TREATMENT FOR OCULAR DISEASES
  申请人：Patel Samir

  公开号：US20110110932A1

  公开（公告）日：2011-05-12

  The invention provides compositions and methods for treating ocular disorders, such as angiogenesis-associated disorders, by administering a combination of an inhibitor of VEGF activity and an inhibitor of α 5 β 1 integrin activity.
• METHODS FOR DETECTING AND INHIBITING ANGIOGENESIS
  申请人：VARNER Judith A.

  公开号：US20110177528A1

  公开（公告）日：2011-07-21

  The present invention provides methods for reducing or inhibiting angiogenesis in a tissue, by contacting α5β1 integrin in the tissue with an agent that interferes with specific binding of the α5β1 integrin to a ligand expressed in the tissue; and methods of identifying angiogenesis in a tissue, by contacting the tissue with an agent that specifically binds α5β1 integrin, and detecting specific binding of the agent to α5β1 integrin associated with a blood vessel in the tissue. Also provided are methods of diagnosing a pathological condition characterized by angiogenesis in a tissue in an individual. The invention further provides methods of reducing or inhibiting angiogenesis in a tissue in an individual, by administering to the individual an agent that interferes with the specific binding of α5β1 integrin to a ligand expressed in the tissue; and methods of reducing the severity of a pathological condition associated with angiogenesis in an individual, by administering to the individual an agent that interferes with specific binding of α5β1 integrin to a ligand in a tissue associated with the pathological condition. The invention also provides methods of identifying an agent that reduces or inhibits angiogenesis associated with α5β1 integrin expression in a tissue by contacting a tissue exhibiting angiogenesis associated with α5β1 integrin expression with an agent, and detecting a reduction or inhibition of angiogenesis in the tissue.
• PHOTORECEPTORS AND PHOTORECEPTOR PROGENITORS PRODUCED FROM PLURIPOTENT STEM CELLS
  申请人：Ocata Therapeutics, Inc.

  公开号：US20160175362A1

  公开（公告）日：2016-06-23

  Methods are provided for the production of photoreceptor cells and photoreceptor progenitor cells from pluripotent stem cells. Additionally provided are compositions of photoreceptor cells and photoreceptor cells, as well as methods for the therapeutic use thereof. Exemplary methods may produce substantially pure cultures of photoreceptor cells and/or photoreceptor cells.