6-[3-[2-(Methylamino)propyl]phenoxy]hexanoic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 6-[3-[2-(Methylamino)propyl]phenoxy]hexanoic acid
• 化学式: C₁₆H₂₅NO₃
• 分子量: 279.37
• InChiKey: DTFNEHJTSZOJJK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  20
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  58.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Monoclonal antibody antagonists for treating medical problems associated with d-amphetamine-like drugs
  申请人：——

  公开号：US20030119083A1

  公开（公告）日：2003-06-26

  The present invention provides synthetic immunochemical haptens for the generation of antibodies that are designed to recognize the common molecular features of d-methamphetamine-like abused stimulants with insignificant cross-reactivity to endogenous substrates (e.g. dopamine) or over-the-counter medications (e.g. 1-methamphetamine, pseudoephedrine, phenylpropanolamine and ephedrine). These monoclonal antibodies and their antigen binding fragments are useful in treatment plans for recovering addicts, in emergency room settings for rapidly reversing a drug overdose, in protection of fetuses from drug-abusing pregnant mothers or in a psychiatric setting to reduce the exacerbation of psychotic disorders caused by stimulant drugs.

  本发明提供了合成免疫化学半抗原，用于产生设计用于识别d-甲基苯丙胺类滥用兴奋剂的共同分子特征的抗体，该抗体与内源性底物（如多巴胺）或非处方药物（如1-甲基苯丙胺、伪麻黄碱、苯丙醇胺和麻黄碱）的交叉反应微不足道。这些单克隆抗体及其抗原结合片段在康复成瘾者的治疗计划、急诊室中快速逆转药物过量、保护胎儿免受滥用药物的孕妇的影响或在精神科环境中减少由兴奋剂药物引起的精神病性障碍的加剧方面是有用的。
• METHAMPHETAMINE-LIKE HAPTEN COMPOUNDS, LINKERS, CARRIERS AND COMPOSITIONS AND USES THEREOF
  申请人：Owens M. Samuel

  公开号：US20070238653A1

  公开（公告）日：2007-10-11

  The invention generally relates to hapten compounds comprising either (+) methamphetamine or (+) amphetamine conjugated to a linker. Generally speaking, hapten compounds of the invention may be used to elicit an immune response to one or more of (+) methamphetamine, (+) amphetamine, or (+) MDMA.
• MONOCLONAL ANTIBODIES THAT SELECTIVELY RECOGNIZE METHAMPHETAMINE AND METHAMPHETAMINE LIKE COMPOUNDS
  申请人：Owens S. Michael

  公开号：US20080125579A1

  公开（公告）日：2008-05-29

  The invention generally relates to monoclonal antibodies that recognize at least one compound from the group consisting of (+) methamphetamine, (+) amphetamine, and (+) 3,4-methylenedioxymethamphetamine ((+) MDMA). Generally speaking, the monoclonal antibodies do not recognize (−) methamphetamine, (−) amphetamine, or (−) MDMA.
• ANTIBODY-NANOPARTICLE CONJUGATES FOR THE TREATMENT OF DRUG ABUSE
  申请人：PETERSON Eric C.

  公开号：US20160030593A1

  公开（公告）日：2016-02-04

  The present invention generally relates to an antibody composition including antibodies conjugated to nanoparticles. The antibody composition may be used in methods to treat drug use, drug addiction, and effects of drug use.
• US6669937B2
  申请人：——

  公开号：US6669937B2

  公开（公告）日：2003-12-30