(2R,4R)-2-[[[5-(4-fluorophenyl)pyridin-3-yl]methylamino]methyl]-3,4-dihydro-2H-chromen-4-ol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: (2R,4R)-2-[[[5-(4-fluorophenyl)pyridin-3-yl]methylamino]methyl]-3,4-dihydro-2H-chromen-4-ol
• 化学式: C₂₂H₂₁FN₂O₂
• 分子量: 364.4
• InChiKey: AEWGSHCHDSLEPV-TZIWHRDSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  54.4
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Novel use of substituted aminomethyl chromans
  申请人：Böttcher Henning

  公开号：US20060229339A1

  公开（公告）日：2006-10-12

  Compounds of formula I in which R has a meaning as indicated in claim 1 , or one of their optical isomers or pharmaceutically acceptable salts, used for the treatment of extrapyramidal movement disorders and/or adverse effects in extrapyramidal movement disorders and/or for the treatment of extrapyramidal symptoms (EPS) induced by neuroleptics.

  公式I中R所表示的含义如权利要求1所述的化合物，或其光学异构体或药学上可接受的盐，用于治疗运动障碍和/或运动障碍的不良反应和/或由神经类药物引起的运动障碍症状（EPS）的治疗。
• NOVEL USE OF SUBSTITUTED AMINOMETHYL CHROMANS
  申请人：MERCK PATENT GmbH

  公开号：EP1427724A1

  公开（公告）日：2004-06-16
• US7618988B2
  申请人：——

  公开号：US7618988B2

  公开（公告）日：2009-11-17
• [EN] NOVEL USE OF SUBSTITUTED AMINOMETHYL CHROMANS<br/>[FR] NOUVELLE UTILISATION DE CHROMANES AMINOMETHYLIQUES SUBSTITUES
  申请人：MERCK PATENT GMBH

  公开号：WO2003024960A1

  公开（公告）日：2003-03-27

  Compounds of formula I in which R has a meaning as indicated in claim 1, or one of their optical isomers or pharmaceutically acce ptable salts, used for the treatment of extrapyramidal movement disorders and/or adverse effects in extrapyramidal movement disorders and/or for the treatment of extrapyramidal symptoms (EPS) induced by neuroleptics.