N-hydroxy-1-(4-methoxyphenyl)sulfonyl-5-oxo-4-prop-2-enylpiperazine-2-carboxamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-hydroxy-1-(4-methoxyphenyl)sulfonyl-5-oxo-4-prop-2-enylpiperazine-2-carboxamide
• 化学式: C₁₅H₁₉N₃O₆S
• 分子量: 369.4
• InChiKey: IBKRMSDSONKHKH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  125
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• Novel sulfonamide derivatives, intermidiate thereof, its preparation methods, and pharmaceutical composition comprising the same
  申请人：——

  公开号：US20040138206A1

  公开（公告）日：2004-07-15

  The present invention relates to a novel sulfonamide derivatives and novel intermediates thereof, preparation thereof, and a pharmaceutical composition comprising the same, and more particularly, to novel sulfonamide derivatives and intermediates thereof that are used as angiogenesis controlling material and that can inhibit overexpression of matrix metalloproteinase that decomposes protein constituents in extracellular and basement membranes of connective tissues, and preparation methods thereof, and a pharmaceutical composition comprising the same.

  本发明涉及一种新的磺酰胺衍生物及其新的中间体，其制备方法，以及包含其的制药组合物，更具体地说，本发明涉及一种用作血管生成控制材料的新型磺酰胺衍生物及其中间体，可以抑制连接组织的细胞外和基底膜中的蛋白质成分分解的基质金属蛋白酶的过度表达，以及其制备方法和包含其的制药组合物。
• EP1389204A4
  申请人：——

  公开号：EP1389204A4

  公开（公告）日：2005-03-23
• NOVEL SULFONAMIDE DERIVATIVES, INTERMEDIATE THEREOF, ITS PREPARATION METHODS, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME
  申请人：Kolon Ind. Inc.

  公开号：EP1389204A1

  公开（公告）日：2004-02-18
• US7223751B2
  申请人：——

  公开号：US7223751B2

  公开（公告）日：2007-05-29
• [EN] NOVEL SULFONAMIDE DERIVATIVES, INTERMEDIATE THEREOF, ITS PREPARATION METHODS, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME<br/>[FR] NOUVEAUX DERIVES DE SULFONAMIDES, LEURS INTERMEDIAIRES, LEURS PROCEDES DE PREPARATION ET COMPOSITION PHARMACEUTIQUE LES CONTENANT
  申请人：KOLON INC

  公开号：WO2002088115A1

  公开（公告）日：2002-11-07

  The present invention relates to a novel sulfonamide derivatives and novel intermediates thereof, preparation thereof, and a pharmaceutical composition comprising the same, and more particularly, to novel sulfonamide derivatives and intermediates thereof that are used as angiogenesis controlling material and that can inhibit overexpression of matrix metalloproteinase that decomposes protein constituents in extracellular matrix and basement membranes of connective tissues, and preparation methods thereof, and a pharmaceutical composition comprising the same.