2,3,8,9-Tetrahydro-7H[1,4]dioxino[2,3-h]chromen-2-ylmethyl 4-methyl-benzenesulfonate | 474552-05-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,3,8,9-Tetrahydro-7H[1,4]dioxino[2,3-h]chromen-2-ylmethyl 4-methyl-benzenesulfonate
• 英文别名: 3,7,8,9-tetrahydro-2H-pyrano[3,2-h][1,4]benzodioxin-2-ylmethyl 4-methylbenzenesulfonate
• CAS: 474552-05-1
• 化学式: C₁₉H₂₀O₆S
• 分子量: 376.43
• InChiKey: KHJKPJWFZNOPGL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  79.4
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• Antidepressant azaheterocyclylmethyl derivatives of 1,4,5-trioxa-phenanthrene
  申请人：Wyeth

  公开号：US20020193401A1

  公开（公告）日：2002-12-19

  Compounds of the formula 1 useful for the treatment of diseases such as depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder attention deficit disorder (with and without hyperactivity), obsessive compulsive disorder (including trichotillomania), social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa, bulimia nervosa, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction and related illnesses.

  该式的化合物用于治疗疾病，如抑郁症（包括但不限于重度抑郁症、儿童抑郁症和慢性抑郁症）、焦虑症、恐慌障碍、创伤后应激障碍、经前期失调性障碍、注意力缺陷障碍（有或无多动症）、强迫症（包括拔毛症）、社交焦虑障碍、广泛性焦虑障碍、肥胖症、进食障碍，如厌食症、暴食症、血管运动潮红、可卡因和酒精成瘾、性功能障碍及相关疾病。
• US6555560B2
  申请人：——

  公开号：US6555560B2

  公开（公告）日：2003-04-29
• US6906206B2
  申请人：——

  公开号：US6906206B2

  公开（公告）日：2005-06-14
• US6943178B2
  申请人：——

  公开号：US6943178B2

  公开（公告）日：2005-09-13
• [EN] ANTIDEPRESSANT AZAHETEROCYCLYLMETHYL DERIVATIVES OF 1,4,5-TRIOXA-PHENANTHRENE<br/>[FR] DERIVES AZAHETEROCYCLYLMETHYLIQUES DE 1,4,5-TRIOXA-PHENANTHRENE ANTIDEPRESSEURS
  申请人：WYETH CORP

  公开号：WO2002088136A2

  公开（公告）日：2002-11-07

  Compounds of the formula (I), useful for the treatment of diseases such as depression (including but not limited to major depressive disorder, childhood depression and dysthymia), anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder attention deficit disorder (with and without hyperactivity), obsessive compulsive disorder (including trichotillomania), social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa, bulimia nervosa, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction and related illnesses.