(5Z)-5-[[4-(2-chlorophenyl)phenyl]methylidene]-1,3-thiazolidine-2,4-dione

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (5Z)-5-[[4-(2-chlorophenyl)phenyl]methylidene]-1,3-thiazolidine-2,4-dione
• 化学式: C₁₆H₁₀ClNO₂S
• 分子量: 315.8
• InChiKey: KAQNLEMLOSASRI-ZROIWOOFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  71.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• EP1501509A4
  申请人：——

  公开号：EP1501509A4

  公开（公告）日：2009-07-15
• ARYL-LINK-ARYL SUBSTITUTED THIAZOLIDINE-DIONE AND OXAZOLIDINE-DIONE AS SODIUM CHANNEL BLOCKERS
  申请人：Merck & Co., Inc.

  公开号：EP1501509A2

  公开（公告）日：2005-02-02
• US7348348B2
  申请人：——

  公开号：US7348348B2

  公开（公告）日：2008-03-25
• [EN] ARYL-LINK-ARYL SUBSTITUTED THIAZOLIDINE-DIONE AND OXAZOLIDINE-DIONE AS SODIUM CHANNEL BLOCKERS<br/>[FR] THIAZOLIDINE-DIONE ET OXAZOLIDINE-DIONE A SUBSTITUTION ARYLE-LIAISON-ARYLE UTILES EN TANT QUE BLOQUEURS DES CANAUX SODIQUES
  申请人：MERCK & CO INC

  公开号：WO2004024061A2

  公开（公告）日：2004-03-25

  Aryl-link-aryl thiazolidine-dione and aryl-link-aryl oxazolidine-dione compounds are sodium channel blockers; pharmaceutical compositions that include an effective amount of the aryl-link-aryl thiazolidine-dione and aryl-link-aryl oxazolidine-dione compounds and a pharmaceutically acceptable carrier; and a method of treatment of acute pain, chronic pain, visceral pain, inflammatory pain, or neuropathic pain, as well as irritable bowel syndrome, Crohns disease, epilepsy, partial and generalized tonic seizures, multiple sclerosis, bipolar depression, and tachy-arrhythmias by the administration of an effective amount of aryl-link-aryl thiazolidine-dione and aryl-link-aryl oxazolidine-dione compounds are described.