N2-(2-chloro-4-fluorobenzyl)-4-methyl-N1-(3-phenylpropyl)pentane-1,2-diamine | 627527-10-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N2-(2-chloro-4-fluorobenzyl)-4-methyl-N1-(3-phenylpropyl)pentane-1,2-diamine
• 英文别名: 2-N-[(2-chloro-4-fluorophenyl)methyl]-4-methyl-1-N-(3-phenylpropyl)pentane-1,2-diamine
• CAS: 627527-10-0
• 化学式: C₂₂H₃₀ClFN₂
• 分子量: 376.945
• InChiKey: BYNTZPNZAGOWGO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  26
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  24.1
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Compositions and methods for the treatment of infectious diseases
  申请人：PROTOPOPOVA Marina Nikolaevna

  公开号：US20110118307A1

  公开（公告）日：2011-05-19

  Methods and compositions for treating disease caused by infectious agents, particularly tuberculosis. In particular, methods and compositions comprising substituted ethylene diamines for the treatment of infectious diseases are provided. In one embodiment, these methods and compositions are used for the treatment of mycobacterial infections, including, but not limited to, tuberculosis.
• US8268894B2
  申请人：——

  公开号：US8268894B2

  公开（公告）日：2012-09-18
• [EN] ANTI-TUBERCULAR DRUGS: COMPOSITIONS AND METHODS<br/>[FR] MEDICAMENTS ANTITUBERCULEUX: COMPOSITIONS ET METHODES
  申请人：SEQUELLA INC

  公开号：WO2007005896A2

  公开（公告）日：2007-01-11

  [EN] Methods and compositions for treating disease caused by infectious agents, particularly tuberculosis. In particular, methods and compositions comprising substituted ethylene diamines for the treatment of infectious diseases are provided. In one embodiment, these methods and compositions are used for the treatment of mycobacterial infections, including, but not limited to, tuberculosis. In certain embodiments, the present invention comprises compositions comprising novel substituted ethylene diamine compounds further comprising antitubercular agents such as rifampicin, isoniazid, pyrazinamide and ethambutol.
  [FR] L'invention concerne des méthodes et des compositions destinées à traiter une maladie causée par des agents infectieux, notamment la tuberculose. L'invention concerne en particulier des méthodes et des compositions comprenant des diamines d'éthylène substitués pour le traitement de maladies infectieuses. Dans un mode de réalisation, ces méthodes et ces compositions sont utilisées pour le traitement d'infections microbiennes comme, mais pas exclusivement, la tuberculose. Dans certains modes de réalisation, l'invention concerne des compositions comprenant de nouveaux composés de diamine d'éthylène substitué contenant en outre des agents antituberculeux, tels que la rifampicine, l'isoniazide, la pyrazinamide et l'éthambutol.