N,N-diethyl-4-[[3-[[2-(5-methylthiophen-2-yl)acetyl]amino]phenyl]-piperidin-4-ylidenemethyl]benzamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N,N-diethyl-4-[[3-[[2-(5-methylthiophen-2-yl)acetyl]amino]phenyl]-piperidin-4-ylidenemethyl]benzamide
• 化学式: C₃₀H₃₅N₃O₂S
• 分子量: 501.7
• InChiKey: PMWMBDGWBCEZPX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  36
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  89.7
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] PHENYL-PIPERIDIN-4-YLIDENE-METHYL-BENZAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN OR GASTROINTESTINAL DISORDERS<br/>[FR] DERIVES DE PHENYL-PIPERIDIN-4-YLIDENE-METHYL-BENZAMIDE POUR LE TRAITEMENT DE LA DOULEUR ET DE TROUBLES GASTRO-INTESTINAUX
  申请人：ASTRAZENECA AB

  公开号：WO2004041784A1

  公开（公告）日：2004-05-21

  Compounds of general formula: wherein R1, R2 and R3 are as defined in the specification, as well as salts, enantiomers thereof and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.

  通式化合物：其中R1、R2和R3如规范中定义，以及它们的盐、对映体和包括这些化合物的药物组合物已准备好。它们在治疗中很有用，特别是在疼痛管理中。
• Phenyl-piperidin-4-ylidene-methyl-benzamide derivatives for the treatment of pain or gastrointestinal disorders
  申请人：Brown William

  公开号：US20060014789A1

  公开（公告）日：2006-01-19

  Compounds of general formula: wherein R 1 , R 2 and R 3 are as defined in the specification, as well as salts, enantiomers thereof and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.

  通式如下的化合物： 其中 R 1 , R 2 和 R 3 及其盐类、对映体以及包括这些化合物的药物组合物。它们可用于治疗，尤其是疼痛治疗。
• PHENYL-PIPERIDIN-4-YLIDENE-METHYL-BENZAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN OR GASTROINTESTINAL DISORDERS
  申请人：AstraZeneca AB

  公开号：EP1567496B1

  公开（公告）日：2007-04-11