[(Z)-octadec-9-enyl] 1-methylpyridin-1-ium-3-carboxylate;iodide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: [(Z)-octadec-9-enyl] 1-methylpyridin-1-ium-3-carboxylate;iodide
• 化学式: C25H42INO2
• 分子量: 515.5
• InChiKey: YRHFGSFYDHFCCL-GMFCBQQYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  3.71
• 重原子数：
  29
• 可旋转键数：
  18
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  30.2
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Basic esters of fatty alcohols and their use as anti-inflammatory or immunomodulatory agents
  申请人：Shinitzky Meir

  公开号：US20060173053A1

  公开（公告）日：2006-08-03

  Basic esters of fatty alcohols of the general formula: R1-O—CO-A or pharmaceutically acceptable salts thereof, wherein R1 is C 12 -C 24 alkyl or C 10 -C 24 alkenyl, and A is a residue containing at least one acyclic or cyclic amino group and/or at least one heteroaromatic ring containing a tertiary or quaternary nitrogen atom, are anti-inflammatory and immunomodulatory agents, useful in the treatment of immunologically-mediated inflammation, as adjuvants for antigens involved in both cellular and humoral responses.

  一般式为R1-O-CO-A的脂肪醇基本酯或其药学上可接受的盐，其中R1为C12-C24烷基或C10-C24烯基，A为含有至少一个无环或环状氨基团和/或至少一个含有三级或四级氮原子的杂环芳香环的残基，具有抗炎和免疫调节作用，可用于治疗免疫介导的炎症，并作为细胞和体液反应中涉及的抗原的佐剂。
• BASIC ESTERS OF FATTY ALCOHOLS AND THEIR USE AS ANTI-INFLAMMATORY OR IMMUNOMODULATORY AGENTS
  申请人：YEDA RESEARCH AND DEVELOPMENT CO. LTD.

  公开号：EP1551495A2

  公开（公告）日：2005-07-13
• US8987263B2
  申请人：——

  公开号：US8987263B2

  公开（公告）日：2015-03-24
• [EN] BASIC ESTERS OF FATTY ALCOHOLS AND THEIR USE AS ANTI-INFLAMMATORY OR IMMUNOMODULATORY AGENTS<br/>[FR] ESTERS DE BASE D'ALCOOLS GRAS ET LEUR UTILISATION COMME AGENTS ANTI-INFLAMMATOIRES OU IMMUNOMODULATEURS
  申请人：YEDA RES & DEV

  公开号：WO2004032824A2

  公开（公告）日：2004-04-22

  Basic esters of fatty alcohols of the general formula: R1-O-CO-A or pharmaceutically acceptable salSt thereof, wherein R1 is C12-C24 alkyl or C10-C24 alkenyl, and A is a residue containing at least one acyclic or cyclic amino group and/or at least one heteroaromatic ring containing a tertiary or quaternary nitrogen atom, are anti-inflammatory and immunomodulatory agents, useful in the treatment of immunologically-mediated inflammation, and as adjuvants for antigens involved in both cellular and humoral responses.