4'-Trifluoromethyl-biphenyl-4-carboxylic acid methyl-{(S)-1-[(R)-3-(3-phenyl-propylamino)-pyrrolidine-1-carbonyl]-pyrrolidin-3-yl}-amide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4'-Trifluoromethyl-biphenyl-4-carboxylic acid methyl-{(S)-1-[(R)-3-(3-phenyl-propylamino)-pyrrolidine-1-carbonyl]-pyrrolidin-3-yl}-amide
• 英文别名: 4''-trifluoromethyl-biphenyl-4-carboxylic acid methyl-{(S)-1-[(R)-3-(3-phenyl-propylamino)-pyrrolidine-1-carbonyl]-pyrrolidin-3-yl}-amide；N-methyl-N-[(3S)-1-[(3R)-3-(3-phenylpropylamino)pyrrolidine-1-carbonyl]pyrrolidin-3-yl]-4-[4-(trifluoromethyl)phenyl]benzamide
• 化学式: C₃₃H₃₇F₃N₄O₂
• 分子量: 578.678
• InChiKey: RCKQSOSJWIPOPL-IHLOFXLRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  42
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  55.9
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  4'-Trifluoromethyl-biphenyl-4-carboxylic acid methyl-((S)-1-{(R)-3-[3-phenyl-prop-(E)-ylideneamino]-pyrrolidine-1-carbonyl}-pyrrolidin-3-yl)-amide 在 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 生成 4'-Trifluoromethyl-biphenyl-4-carboxylic acid methyl-{(S)-1-[(R)-3-(3-phenyl-propylamino)-pyrrolidine-1-carbonyl]-pyrrolidin-3-yl}-amide
  参考文献：
  名称：

  Synthesis and structure–activity relationships of retro bis-aminopyrrolidine urea (rAPU) derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1). Part 1

  摘要：

  The design, synthesis, and SAR of a series of retro bis-aminopyrrolidine ureas are described. Compounds from this series exhibited potent binding affinity and functional activity at MCH-R1, and good oral bioavailability in rat. (c) 2006 Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmcl.2006.06.045

文献信息

• Synthesis and structure–activity relationships of retro bis-aminopyrrolidine urea (rAPU) derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1). Part 1
  作者：Martin W. Rowbottom、Troy D. Vickers、Brian Dyck、Jonathan Grey、Junko Tamiya、Mingzhu Zhang、Mehrak Kiankarimi、Dongpei Wu、Wesley Dwight、Warren S. Wade、David Schwarz、Christopher E. Heise、Ajay Madan、Andrew Fisher、Robert Petroski、Val S. Goodfellow

  DOI：10.1016/j.bmcl.2006.06.045

  日期：2006.9

  The design, synthesis, and SAR of a series of retro bis-aminopyrrolidine ureas are described. Compounds from this series exhibited potent binding affinity and functional activity at MCH-R1, and good oral bioavailability in rat. (c) 2006 Published by Elsevier Ltd.