N-[5-tert-butyl-3-(methanesulfonamido)-2-methoxyphenyl]-1-methyl-7-[2-(1-methylpiperidin-4-yl)oxypyrimidin-4-yl]oxyindole-2-carboxamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[5-tert-butyl-3-(methanesulfonamido)-2-methoxyphenyl]-1-methyl-7-[2-(1-methylpiperidin-4-yl)oxypyrimidin-4-yl]oxyindole-2-carboxamide
• 化学式: C₃₂H₄₀N₆O₆S
• 分子量: 636.8
• InChiKey: LFOJEZYRFOINLU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  45
• 可旋转键数：
  10
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  145
• 氢给体数：
  2
• 氢受体数：
  10

文献信息

• HETEROCYCLIC N-ARYL CARBOXAMIDES AS CYTOKINE INHIBITORS
  申请人：Boehringer Ingelheim Pharmaceuticals Inc.

  公开号：EP1631567A2

  公开（公告）日：2006-03-08
• US7335657B2
  申请人：——

  公开号：US7335657B2

  公开（公告）日：2008-02-26
• [EN] HETEROCYCLIC N-ARYL CARBOXAMIDES AS CYTOKINE INHIBITORS<br/>[FR] INHIBITEURS DE LA CYTOKINE
  申请人：BOEHRINGER INGELHEIM PHARMA

  公开号：WO2005016918A2

  公开（公告）日：2005-02-24

  Disclosed are compounds of formula (I) where Ar1, X, Y, Q, W, R3, R4, R5, R6 and Ry are defined herein. The compounds of the invention inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds.