N-(6-oxo-2,6-dihydro-dibenzo[cd,g]indazol-5-yl)-acetamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: N-(6-oxo-2,6-dihydro-dibenzo[cd,g]indazol-5-yl)-acetamide
• 英文别名: 5-(acetylamino)anthra[1,9cd]pyrazol-6(2H)-one；N-(6-oxo-2,6-dihydro-2H-dibenzo[cd,g]indazol-5-yl)-acetamide；N-(8-oxo-14,15-diazatetracyclo[7.6.1.02,7.013,16]hexadeca-1(15),2,4,6,9,11,13(16)-heptaen-10-yl)acetamide
• 化学式: C₁₆H₁₁N₃O₂
• 分子量: 277.282
• InChiKey: BZUVILGDGQDJTP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  74.8
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Methods of using and compositions comprising a JNK inhibitor for the treatment, prevention, management and/or modification of pain
  申请人：——

  公开号：US20040087642A1

  公开（公告）日：2004-05-06

  The present invention relates to methods for treating, preventing, managing and/or modifying pain, comprising administering an effective amount of a JNK Inhibitor to a patient in need thereof. Specific embodiments encompass the administration of a JNK Inhibitor, alone or in combination with a second active agent and/or surgery or physical therapy. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in methods of the invention are also disclosed.

  本发明涉及治疗、预防、控制和/或改变疼痛的方法，包括向有需要的患者施用有效量的JNK抑制剂。具体的实施方案包括单独或与第二种活性剂和/或手术或物理疗法联合使用 JNK 抑制剂。本发明还公开了适用于本发明方法的药物组合物、单一单位剂型和试剂盒。
• METHODS OF USING AND COMPOSITIONS COMPRISING A JNK INHIBITOR FOR THE TREATMENT, PREVENTION, MANAGEMENT AND/OR MODIFICATION OF PAIN
  申请人：CELGENE CORPORATION

  公开号：EP1553951A2

  公开（公告）日：2005-07-20
• EP1553951A4
  申请人：——

  公开号：EP1553951A4

  公开（公告）日：2008-06-11
• JNK INHIBITORS FOR THE TREATMENT OF CNS INJURY
  申请人：CELGENE CORPORATION

  公开号：EP1827422A2

  公开（公告）日：2007-09-05
• Composition for collecting and preserving placental stem cells and methods of using the composition
  申请人：Edinger W. James

  公开号：US20070190042A1

  公开（公告）日：2007-08-16

  The present invention provides improved compositions and methods for the collection of stem cells from an organ, e.g., placenta. The invention provides a stem cell collection composition comprising an apoptosis inhibitor and, optionally, an enzyme such as a protease or mucolytic enzyme, vasodilator, necrosis inhibitor, oxygen-carrying perfluorocarbon, or an organ preserving compound. The invention provides methods of using the stem cell collection composition to collect stem cells and to preserve populations of stem cells.