2-(4-fluorophenyl)-4-(5-(6-methyl)-pyridin-2-yl-3H-[1,2,3]triazol-4-yl)-pyridine | 656800-39-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-(4-fluorophenyl)-4-(5-(6-methyl)-pyridin-2-yl-3H-[1,2,3]triazol-4-yl)-pyridine
• 英文别名: 2-(4-fluorophenyl)-4-[5-(6-methylpyridin-2-yl)-2H-triazol-4-yl]pyridine
• CAS: 656800-39-4
• 化学式: C₁₉H₁₄FN₅
• 分子量: 331.352
• InChiKey: FEOLPLMQUUCRLS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  67.4
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] PYRIDINYL SUBSTITUTED (1,2,3,)TRIAZOLES AS INHIBITORS OF THE TGF-BETA SIGNALLING PATHWAY<br/>[FR] (1, 2, 3) TRIAZOLES SUBSTITUES DE PYRIDINYL UTILISES COMME INHIBITEURS DE LA VOIE DE SIGNALISATION TGF-BETA
  申请人：SMITHKLINE BEECHAM CORP

  公开号：WO2004013125A1

  公开（公告）日：2004-02-12

  The invention relates to novel triazole derivatives which are inhibitors of the transforming growth factor, ('TGF')-ß signalling pathway, in particular, the phosphorylation of smad2 or smad3 by the TGF-β type I or activin-like kinase ('ALK')-5 receptor, methods for their preparation and their use in medicine, specifically in the treatment and prevention of a disease state mediated by this pathway.

  这项发明涉及新型三唑衍生物，它们是转化生长因子（'TGF'-ß）信号通路的抑制剂，特别是通过TGF-β类型I或类活化素激酶（'ALK'-5）受体对smad2或smad3的磷酸化的抑制剂，以及其制备方法和在医学中的使用，具体用于治疗和预防由该通路介导的疾病状态。
• Pyridinyl substituted (1,2,3,)triazoles as inhibitors of the tgf-beta signalling pathway
  申请人：Gellibert Jeanne Francoise

  公开号：US20060074244A1

  公开（公告）日：2006-04-06

  The invention relates to novel triazole derivatives which are inhibitors of the transforming growth factor, (“TGF”)-β signalling pathway, in particular, the phosphorylation of smad2 or smad3 by the TGF-β type I or activin-like kinase (“ALK”)-5 receptor, methods for their preparation and their use in medicine, specifically in the treatment and prevention of a disease state mediated by this pathway.

  本发明涉及新型三唑衍生物，其是转化生长因子（“TGF”）-β信号通路的抑制剂，特别是通过TGF-β类型I或类活化素激酶（“ALK”）-5受体对smad2或smad3的磷酸化，其制备方法以及它们在医学上的用途，特别是在治疗和预防由该通路介导的疾病状态中的应用。
• PYRIDINYL SUBSTITUTED (1,2,3,)TRIAZOLES AS INHIBITORS OF THE TGF-BETA SIGNALLING PATHWAY
  申请人：SMITHKLINE BEECHAM CORPORATION

  公开号：EP1530567A1

  公开（公告）日：2005-05-18
• EFFICIENT INDUCTION OF PLURIPOTENT STEM CELLS USING SMALL MOLECULE COMPOUNDS
  申请人：Ichida Justin

  公开号：US20120021519A1

  公开（公告）日：2012-01-26

  The disclosure features a method of producing a reprogrammed cell (e.g. an induced pluripotent stem cell or an undifferentiated cell) from a differentiated (e.g. somatic) cell. In some embodiments, the methods includes contacting a differentiated (e.g. somatic cell) with a TGFBR1 inhibitor or anti-TGF-β-antibody to produce a reprogrammed cell (e.g. pluripotent stem cell or undifferentiated cell). Embodiments of the present invention relate to a reprogrammed cell and methods and compositions for producing a chemically produced reprogrammed cell or populations thereof.