N-(2-amino-phenyl)-4-[(4-methyl-pentanoylamino)-methyl]benzamide | 709665-03-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(2-amino-phenyl)-4-[(4-methyl-pentanoylamino)-methyl]benzamide
• 英文别名: N-(2-aminophenyl)-4-[(4-methylpentanoylamino)methyl]benzamide
• CAS: 709665-03-2
• 化学式: C₂₀H₂₅N₃O₂
• 分子量: 339.437
• InChiKey: NMDFLQBAKFYBHT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  25
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  84.2
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• [EN] ARYLENE-CARBOXYLIC ACID (2-AMINO-PHENYL)-AMIDE DERIVATIVES AS PHARMACEUTICAL AGENTS<br/>[FR] DERIVES DE (2-AMINO-PHENYL)-AMIDE D'ACIDE ARYLENE-CARBOXYLIQUE SERVANT D'AGENTS PHARMACEUTIQUES
  申请人：HOFFMANN LA ROCHE

  公开号：WO2004052838A1

  公开（公告）日：2004-06-24

  The present invention describes compounds of general formula (I), a process for their manufacture, medicaments containing them and their manufacture as well as the use of these compounds as pharmaceutical agents. The compounds according to this invention show antiproliferative and differentiation- inducing activity, which results in inhibition of tumor cell proliferation, induction of apoptosis and inhibition of invasion.

  本发明描述了一般式(I)的化合物，其制备方法，含有这些化合物的药物及其制备方法，以及将这些化合物用作药用剂的用途。根据本发明的化合物显示出抗增殖和诱导分化活性，导致抑制肿瘤细胞增殖，诱导凋亡和抑制侵袭。
• Novel arylene-carboxylic acid (2-amino-phenyl)-amide derivatives
  申请人：——

  公开号：US20040138270A1

  公开（公告）日：2004-07-15

  The present invention describes compounds of the general formula I 1 as well as processes for their manufacture, pharmaceutical compositions containing them and methods for using these compounds and pharmaceutical compositions as pharmaceutical agents. The compounds according to this invention show antiproliferative and differentiation-inducing activity, which results in inhibition of tumor cell proliferation, induction of apoptosis and inhibition of invasion.

  本发明描述了一般式I1的化合物，以及制造它们的过程，包含它们的药物组合物以及将这些化合物和药物组合物用作药物制剂的方法。根据本发明的化合物表现出抗增殖和诱导分化的活性，这导致抑制肿瘤细胞增殖、诱导凋亡和抑制侵袭。
• ARYLENE-CARBOXYLIC ACID (2-AMINO-PHENYL)-AMIDE DERIVATIVES AS PHARMACEUTICAL AGENTS
  申请人：F. HOFFMANN-LA ROCHE AG

  公开号：EP1572625A1

  公开（公告）日：2005-09-14
• US7098247B2
  申请人：——

  公开号：US7098247B2

  公开（公告）日：2006-08-29