N-[(3S)-1-[4-[(4-fluorophenyl)methoxy]phenyl]-5-oxopyrrolidin-3-yl]acetamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: N-[(3S)-1-[4-[(4-fluorophenyl)methoxy]phenyl]-5-oxopyrrolidin-3-yl]acetamide
• 化学式: C₁₉H₁₉FN₂O₃
• 分子量: 342.4
• InChiKey: NKFWUEKCDLNODF-INIZCTEOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  58.6
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] PYRROLIDONE DERIVATIVES AS MAOB INHIBITORS<br/>[FR] DERIVES DE PYRROLIDONE TELS QUE DES INHIBITEURS MAOB
  申请人：HOFFMANN LA ROCHE

  公开号：WO2004026825A1

  公开（公告）日：2004-04-01

  Racemic or enantiomerically pure 4-pyrrolidino derivatives of the formula (I), processes for their preparation, pharmaceutical compositions comprising said derivatives, and their use in the prevention and treatment of a disease which is mediated by a monoamine oxidase B inhibitor, in particular Alzheimer's disease and senile dementia.

  光学异构体或对映纯的式(I)的4-吡咯啉衍生物，其制备方法，包含该衍生物的药物组合物，以及其在通过单胺氧化酶B抑制剂介导的疾病的预防和治疗中的用途，特别是阿尔茨海默病和老年性痴呆症。
• 4-Pyrrolidino-phenyl-benzyl ether derivatives
  申请人：——

  公开号：US20040116707A1

  公开（公告）日：2004-06-17

  The invention relates to racemic or enantiomerically pure 4-pyrrolidino derivatives, processes for their preparation, pharmaceutical compositions comprising said derivatives, and their use in the prevention and treatment of a disease which is mediated by a monoamine oxidase B inhibitor, in particular Alzheimer's disease and senile dementia.

  本发明涉及外消旋或对映纯的4-吡咯烷基衍生物，其制备方法，含有该衍生物的药物组合物，以及它们在预防和治疗由单胺氧化酶B抑制剂介导的疾病中的应用，特别是阿尔茨海默病和老年性痴呆症。
• PYRROLIDONE DERIVATIVES AS MAOB INHIBITORS
  申请人：F.HOFFMANN-LA ROCHE AG

  公开号：EP1542970A1

  公开（公告）日：2005-06-22
• MAO-B INHIBITORS USEFUL FOR TREATING OBESITY
  申请人：McElroy Francis John

  公开号：US20070078172A1

  公开（公告）日：2007-04-05

  The invention provides a method of treating obesity, diabetes, and/or cardiometabolic disorders (e.g., hypertension, dyslipidemias, high blood pressure, and insulin resistance) in a mammal by administering to the mammal a therapeutically effective amount of an irreversible MAO-B inhibitor.
• US7151111B2
  申请人：——

  公开号：US7151111B2

  公开（公告）日：2006-12-19