3-methyl-1-phenylhexan-2-amine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-methyl-1-phenylhexan-2-amine
• 化学式: C₁₃H₂₁N
• 分子量: 191.316
• InChiKey: INMQIUVMYXALHO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-甲基戊醛 在 lithium 作用下， 以 乙醚 为溶剂， 反应 0.5h， 生成 3-methyl-1-phenylhexan-2-amine
  参考文献：
  名称：

  Convenient Access to Primary Amines by Employing the Barbier-Type Reaction of N-(Trimethylsilyl)imines Derived from Aromatic and Aliphatic Aldehydes

  摘要：

  A new versatile preparation of primary amines via benzylation of aromatic and aliphatic aldimines is described. Sonochemical and traditional methods for generation of the reactive intermediates are compared and contrasted. Competitive reactions were analyzed via free energy relationships to support the proposed alkylative mechanism.

  DOI：

  10.1021/jo971061r

文献信息

• Convenient Access to Primary Amines by Employing the Barbier-Type Reaction of <i>N</i>-(Trimethylsilyl)imines Derived from Aromatic and Aliphatic Aldehydes
  作者：Ferenc Gyenes、Kathryn E. Bergmann、John T. Welch

  DOI：10.1021/jo971061r

  日期：1998.5.1

  A new versatile preparation of primary amines via benzylation of aromatic and aliphatic aldimines is described. Sonochemical and traditional methods for generation of the reactive intermediates are compared and contrasted. Competitive reactions were analyzed via free energy relationships to support the proposed alkylative mechanism.