5-Dihydroxymethyl benzoic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-Dihydroxymethyl benzoic acid
• 英文别名: 3-(dihydroxymethyl)benzoic acid
• 化学式: C₈H₈O₄
• 分子量: 168.15
• InChiKey: SBAGBQUDFHHUKH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  77.8
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• [EN] CRYSTALLINE FORM OF ELTROMBOPAG FREE ACID<br/>[FR] FORME CRISTALLINE D'ACIDE LIBRE ELTROMBOPAG
  申请人：HETERO RESEARCH FOUNDATION

  公开号：WO2016035018A1

  公开（公告）日：2016-03-10

  The present invention relates to crystalline form of Eltrombopag free acid and its process for preparation.

  这项发明涉及艾曲莫帕格游离酸的结晶形式及其制备方法。
• INTEGRIN ANTAGONIST CONJUGATES FOR TARGETED DELIVERY TO CELLS EXPRESSING LFA-1
  申请人：Hoffmann-La Roche Inc.

  公开号：US20130197059A1

  公开（公告）日：2013-08-01

  The invention relates to compounds of formula I: wherein R1, R2, and n are defined in the detailed description and claims. In particular, the present invention relates to the compounds of formula I for use in the manufacture and delivery of conjugated moieties such as small molecules, peptides, nucleic acids, fluorescent moieties, and polymers which are linked to LFA-1 integrin antagonists to target cells expressing LFA-1.

  该发明涉及以下式I的化合物：其中R1、R2和n在详细说明和权利要求中有定义。具体而言，本发明涉及式I的化合物用于制备和传递共轭基团，如小分子、肽、核酸、荧光基团和聚合物，这些共轭基团与LFA-1整合素拮抗剂连接，以靶向表达LFA-1的细胞。
• [EN] TRICYCLIC DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, THEIR PREPARATIONS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM<br/>[FR] DERIVES TRICYCLIQUES OU SELS PHARMACEUTIQUEMENT ACCEPTABLES DE CES DERIVES, LEURS PREPARATIONS ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT
  申请人：JE IL PHARMACEUTICAL CO LTD

  公开号：WO2004113281A1

  公开（公告）日：2004-12-29

  The present invention relates to tricyclic derivatives or pharmaceutically acceptable salts thereof, their preparations and pharmaceutical compositions containing them. More precisely, the present invention relates to tricyclic derivatives as colchicine derivatives, pharmaceutically acceptable salts thereof, their preparations and pharmaceutical compositions containing them. Tricyclic derivatives of the present invention show very powerful cytotoxicity to cancer cell lines but were much less toxic than colchicine or taxol, confirmed through animal toxicity test. Tricyclic derivatives of the invention also decrease the volume and weight of a tumor and have a strong angiogenesis inhibiting activity in HUVEC cells. Thus, tricyclic derivatives of the present invention can effectively be used as an anticancer agent, anti-proliferation agent and an angiogenesis inhibitor.

  本发明涉及三环衍生物或其药用盐，其制备以及含有它们的药物组合物。更准确地说，本发明涉及三环衍生物作为秋水仙碱衍生物，其药用盐，其制备以及含有它们的药物组合物。本发明的三环衍生物对癌细胞系表现出非常强大的细胞毒性，但比秋水仙碱或紫杉醇毒性要小得多，经动物毒性试验证实。本发明的三环衍生物还可以减小肿瘤的体积和重量，并且在HUVEC细胞中具有强大的抑制血管生成活性。因此，本发明的三环衍生物可以有效地用作抗癌剂、抗增殖剂和血管生成抑制剂。
• Dendrimers multivalently substituted with active groups
  申请人：Universiteit Utrecht Holding B.V.

  公开号：EP1733742A1

  公开（公告）日：2006-12-20

  The present invention relates to dendrimers being multivalently substituted with active groups, as well as to processes for the preparation thereof and to the use of such multivalent dendrimers. The active compounds encompass peptides, including oligopeptides up to entire proteins, carbohydrates and pharmaceutically active drug molecules. Active compounds are chemoselectively bound to the dendrimer periphery using a cycloaddition reaction (also termed as "click" reaction) between an alkyne group and either an azide or a nitrile oxide, leading to a 1,4-disubstituted 1,2,3-triazole or a 1,4-disubstituted 1,2-oxazole bridging unit. Such reaction is catalyzed by Cu(I) compounds. Microwave irradiation improves the efficiency of the click reaction.

  本发明涉及被多价活性基团取代的树枝状聚合物，以及其制备方法和这种多价树脂的用途。活性化合物包括肽，包括寡肽直至整个蛋白质，碳水化合物和药用活性药物分子。活性化合物通过环加成反应（也称为“点击”反应）与树脂周围的树枝状聚合物具有化学选择性地结合，其中环加成反应是通过炔基与偶氮基或亚硝基氧化物之间的反应实现的，从而形成1,4-二取代的1,2,3-三唑或1,4-二取代的1,2-噁唑桥联单元。这种反应由Cu(I)化合物催化。微波辐射提高了点击反应的效率。
• Methods for the esterification of alcohols and compounds useful therefor as potential anticancer agents
  申请人：Emory University

  公开号：US20020087026A1

  公开（公告）日：2002-07-04

  The invention relates to a method for preparing an ester, by admixing a compound having the structure I: 1 with a base and a compound composed of an alcohol, an alkoxide, or a combination thereof.

  本发明涉及一种制备酯的方法，通过将具有I:1结构的化合物与碱和由醇，碱金属醇盐或两者组合而成的化合物混合。