(4-dimethylamino-6-methylpyridin-2-yl)(pentafluorophenyl)methanol

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (4-dimethylamino-6-methylpyridin-2-yl)(pentafluorophenyl)methanol
• 英文别名: [4-(Dimethylamino)-6-methylpyridin-2-yl]-(2,3,4,5,6-pentafluorophenyl)methanol；[4-(dimethylamino)-6-methylpyridin-2-yl]-(2,3,4,5,6-pentafluorophenyl)methanol
• 化学式: C₁₅H₁₃F₅N₂O
• 分子量: 332.273
• InChiKey: OGWZTAYPNBKTNZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  36.4
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  2-bromo-6-methyl-4-(dimethylamino)pyridine 在 正丁基锂 、 magnesium 作用下， 以 四氢呋喃 、 乙醚 、 正己烷 为溶剂， 反应 0.08h， 生成 (4-dimethylamino-6-methylpyridin-2-yl)(pentafluorophenyl)methanol
  参考文献：
  名称：

  O-Nucleophilic Amino Alcohol Acyl-Transfer Catalysts:  the Effect of Acidity of the Hydroxyl Group on the Activity of the Catalyst

  摘要：

  [GRAPHIC]Amino alcohol-derived acyl-transfer catalysts are shown to operate by an O-nucleophilic mechanism, and catalysts bearing electron-withdrawing groups in proximity to the hydroxyl group are found to be more active. This is attributed to an increase in the acidity of the hydroxyl group of the catalyst.

  DOI：

  10.1021/ol035510n

文献信息

• <i>O</i>-Nucleophilic Amino Alcohol Acyl-Transfer Catalysts:  the Effect of Acidity of the Hydroxyl Group on the Activity of the Catalyst
  作者：Kjirsten A. Wayman、Tarek Sammakia

  DOI：10.1021/ol035510n

  日期：2003.10.1

  [GRAPHIC]Amino alcohol-derived acyl-transfer catalysts are shown to operate by an O-nucleophilic mechanism, and catalysts bearing electron-withdrawing groups in proximity to the hydroxyl group are found to be more active. This is attributed to an increase in the acidity of the hydroxyl group of the catalyst.