4-[10,15,20-Tris(4-aminophenyl)porphyrin-5-yl]aniline

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四吡咯及其衍生物
• 英文名称: 4-[10,15,20-Tris(4-aminophenyl)porphyrin-5-yl]aniline
• 化学式: C₄₄H₃₂N₈
• 分子量: 672.8
• InChiKey: DRHPOBXHJWXPNY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.9
• 重原子数：
  52
• 可旋转键数：
  4
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  154
• 氢给体数：
  4
• 氢受体数：
  8

文献信息

• [EN] CROSS-LINKING METHOD AND APPLICATIONS IN BIOCONJUGATION<br/>[FR] PROCÉDÉ DE RÉTICULATION ET APPLICATIONS EN BIOCONJUGAISON
  申请人：UNIV DURHAM

  公开号：WO2022038359A1

  公开（公告）日：2022-02-24

  The invention relates to a vinyl disulfone compound of general formula (I) In which X, which may be present or absent, is an organic moiety comprising from 1 to 16 carbon atoms; Y is a fluorophore or biomolecule; R1 is an organic moiety comprising from 1 to 16 carbon atoms, together with Y forms part of the fluorophore or biomolecule, or R1 corresponds to X-Y as defined previously; R2 is a C1-C3 alkyl or -CH2-Z in which Z is O, N, S or a halide; and R3 and R4 are independently selected from H, an alkyl group or an aryl group. The invention also relates to methods of preparing bioconjugates using the compound of formula (I), and bioconjugates prepared thereby.

  本发明涉及一种一般式为（I）的乙烯基二硫酰化合物，其中X可以存在或不存在，是由1至16个碳原子组成的有机基团; Y是荧光物或生物分子; R1是由1至16个碳原子组成的有机基团，与Y一起形成荧光物或生物分子一部分，或R1对应于先前定义的X-Y; R2是C1-C3烷基或-CH2-Z，其中Z是O、N、S或卤素; R3和R4独立选择自H、烷基或芳基。本发明还涉及使用式(I)化合物制备生物共轭物的方法以及由此制备的生物共轭物。
• Electrode for active oxygen species and sensor using the electrode
  申请人：Yuasa Makoto

  公开号：US20050077192A1

  公开（公告）日：2005-04-14

  An electrode for active oxygen species comprising a conductive component with a polymer membrane of a metal porphyrin complex formed on the surface is disclosed. The electrode for active oxygen species can detect active oxygen species such as superoxide anion radicals, hydrogen peroxide, and .OH and other active radical species (NO, ONOO—, etc.) in any environment including in vivo environment as well as in vitro environment. The electrode thus can be used for specifying various diseases and examining active oxygen species in food or in water such as tap water and sewage water.

  本发明公开了一种活性氧物种电极，其包括一个导电组件和形成在其表面上的金属卟啉复合物聚合物膜。该活性氧物种电极可以检测任何环境中的活性氧物种，包括体内环境和体外环境中的超氧阴离子自由基、过氧化氢和.OH等活性自由基物种（NO、ONOO-等）。因此，该电极可用于指定各种疾病，并检查食品或水中的活性氧物种，如自来水和污水。
• ELECTRODE FOR ACTIVE OXYGEN SPECIES AND SENSOR USING THE ELECTRODE
  申请人：YUASA Makoto

  公开号：US20110315551A1

  公开（公告）日：2011-12-29

  An electrode for active oxygen species comprising a conductive component with a polymer membrane of a metal porphyrin complex formed on the surface is disclosed. The electrode for active oxygen species can detect active oxygen species such as superoxide anion radicals, hydrogen peroxide, and .OH and other active radical species (NO, ONOO—, etc.) in any environment including in vivo environment as well as in vitro environment. The electrode thus can be used for specifying various diseases and examining active oxygen species in food or in water such as tap water and sewage water.

  公开了一种用于活性氧物种的电极，其中包括一个导电组分和在其表面形成的金属卟啉复合物的聚合物膜。该电极可以检测任何环境中的活性氧物种，包括体内环境和体外环境中的超氧阴离子自由基、过氧化氢、.OH和其他活性自由基物种（NO、ONOO—等）。因此，该电极可用于指定各种疾病并检查食品或水中的活性氧物种，例如自来水和污水。
• ACTIVE OXYGEN SPECIES MEASURING DEVICE
  申请人：Yuasa, Makoto

  公开号：EP1600766A1

  公开（公告）日：2005-11-30

  A reactive oxygen species measuring device according to the present invention comprises a reactive oxygen species sensor provided with an electrode assembly capable of detecting the presence of reactive oxygen species or the like in terms of an electric current, a power source means for applying a measuring voltage to the reactive oxygen species sensor, and a reactive oxygen species concentration measuring means for measuring a concentration of the reactive oxygen species or the like from the current detected by the reactive oxygen species sensor. According to the present invention, a concentration of reactive oxygen species or the like such as in vivo or in vitro superoxide anion radical (O2-.) can be measured reliably, and the entire device can be formed in a smaller size and always mounted to a living body. In addition, the measured data can be transmitted to a remote place or location, and further, the health condition of a living body or the like determined in the remote place can be returned to a measuring place and informed, and thus, the health condition of the living body can be monitored by measuring and monitoring reactive oxygen species.

  根据本发明，一种活性氧测量装置包括一个活性氧传感器，其电极组件能够以电流形式检测活性氧或类似物的存在；一个电源装置，用于向活性氧传感器施加测量电压；以及一个活性氧浓度测量装置，用于根据活性氧传感器检测到的电流测量活性氧或类似物的浓度。根据本发明，可以可靠地测量体内或体外超氧阴离子自由基（O2-.）等活性氧或类似物的浓度，而且整个装置可以形成较小的尺寸，并始终安装在活体上。此外，还可将测量数据传输到远程地点或位置，并进一步将远程地点确定的活体或类似物的健康状况返回到测量地点并告知，因此可通过测量和监测活性氧来监测活体的健康状况。
• CROSSLINKED COMPOSITION
  申请人：Daicel Corporation

  公开号：EP2559720A1

  公开（公告）日：2013-02-20

  To provide a composition (e.g., a coating composition) useful for forming an organic semiconductor having excellent conductivity, solvent resistance, heat resistance, durability, and other properties, and an organic semiconductor formed with the composition. The composition comprises an aromatic polycarbonyl compound having a carbonyl group as a reactive site, and at least one aromatic reactive component selected from an aromatic polyamine having an amino group as a reactive site, and an aromatic heterocyclic compound having a plurality of unmodified α-carbon positions, as reactive sites, each of which is adjacent to a hetero atom of a heterocycl thereof. When the aromatic reactive component is an aromatic heterocyclic compound, the aromatic polycarbonyl compound is an aromatic polyaldehyde compound. Use of the composition in which at least one component of the aromatic polycarbonyl compound and the aromatic reactive component has not less than 3 reactive sites per molecule forms an organic semiconductor having a three-dimensional crosslinked structure.

  提供一种可用于形成具有优异导电性、耐溶剂性、耐热性、耐久性和其他性能的有机半导体的组合物（例如涂层组合物），以及用该组合物形成的有机半导体。 该组合物包括具有羰基作为反应位点的芳香族聚碳化合物，以及至少一种芳香族反应性成分，该芳香族反应性成分选自具有氨基作为反应位点的芳香族多胺和具有多个未修饰的α-碳位作为反应位点的芳香族杂环化合物，其中每个反应位点都与杂环的杂原子相邻。当芳香活性组分为芳香杂环化合物时，芳香多羰基化合物为芳香多醛化合物。使用芳香族多羰基化合物和芳香族活性组分中至少一种组分每分子具有不少于 3 个活性位点的组合物，可形成具有三维交联结构的有机半导体。