4-(meta-nitrophenyl)-1,4-dihydropyridine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(meta-nitrophenyl)-1,4-dihydropyridine
• 英文别名: 4-(3-Nitrophenyl)-1,4-dihydropyridine
• 化学式: C₁₁H₁₀N₂O₂
• 分子量: 202.213
• InChiKey: VFBFJCVHDWGNFF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  57.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-(meta-nitrophenyl)-1,4-dihydropyridine 在 dipotassium peroxodisulfate 作用下， 以 乙腈 为溶剂， 反应 2.5h， 以90%的产率得到4-(3-硝基苯基)吡啶
  参考文献：
  名称：

  Memarian; Mohammadpoor-Baltork; Sadeghi, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2001, vol. 40, # 8, p. 727 - 728

  摘要：

  DOI：

文献信息

• Topical nifedipine formulations and uses thereof
  申请人：University of Saskatchewan

  公开号：US10543202B2

  公开（公告）日：2020-01-28

  The present application relates to topical formulations in the form of an oil-in-water emulsion comprising nifedipine and a photostabilizing effective amount of quercetin or a photostabilizing effective amount of a combination of quercetin and butyl methoxydibenzoylmethane (BMDBM). Such topical formulations may, for example, be used for the treatment of diseases, disorders or conditions that benefit from topical administration of nifedipine such as but not limited to Raynaud phenomenon, chilblains or wound healing.

  本申请涉及水包油乳剂形式的外用制剂，其中包含硝苯地平和光稳定有效量的槲皮素或光稳定有效量的槲皮素和丁基甲氧基二苯甲酰基甲烷（BMDBM）的组合。这种外用制剂可用于治疗从硝苯地平外用给药中获益的疾病、失调或病症，例如但不限于雷诺现象、冻疮或伤口愈合。
• 1,4-Dihydropyridine derivatives
  申请人：KYOWA HAKKO KOGYO CO., LTD.

  公开号：EP0106276B1

  公开（公告）日：1988-10-26
• Derivatives of dihydropyridine and production thereof
  申请人：NIPPON SHINYAKU COMPANY, LIMITED

  公开号：EP0121117B1

  公开（公告）日：1989-08-30
• TOPICAL NIFEDIPINE FORMULATIONS AND USES THEREOF
  申请人：University of Saskatchewan

  公开号：US20180344714A1

  公开（公告）日：2018-12-06

  The present application relates to topical formulations in the form of an oil-in-water emulsion comprising nifedipine and a photostabilizing effective amount of quercetin or a photostabilizing effective amount of a combination of quercetin and butyl methoxydibenzoylmethane (BMDBM). Such topical formulations may, for example, be used for the treatment of diseases, disorders or conditions that benefit from topical administration of nifedipine such as but not limited to Raynaud phenomenon, chilblains or wound healing.
• Memarian; Mohammadpoor-Baltork; Sadeghi, Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2001, vol. 40, # 8, p. 727 - 728
  作者：Memarian、Mohammadpoor-Baltork、Sadeghi、Samani

  DOI：——

  日期：——