Imino-[2-(2-nitrophenyl)phenyl]iminoazanium

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Imino-[2-(2-nitrophenyl)phenyl]iminoazanium
• 化学式: C12H9N4O2+
• 分子量: 241.23
• InChiKey: FQPWFUBIUBNOCF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.44
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  83
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Reduced Toxicity Methotrexate Formulations and Methods for Using the Same
  申请人：Fogarty Patrick

  公开号：US20080312201A1

  公开（公告）日：2008-12-18

  Methods of using methotrexate (MTX) active agents in which reduced host toxicity is observed are provided. In the subject methods, an effective amount of an MTX active agent is administered to the host in conjunction with the administration of an MTX toxicity reducing agent of the present invention. Also provided are compositions for use in practicing the subject methods, e.g., pharmaceutical compositions having reduced toxicity, in which the MTX active agent is combined with an MTX toxicity reducing agent that reduces the level of undesired MTX toxicity while maintaining an effective MTX anti-proliferative activity. Also provided are methods of using the subject methods and compositions in the treatment of a variety of different disease conditions.