3-(2,4-Dichlorobenzyl)-6-(methylsulfanyl)pyridazine | 241132-71-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(2,4-Dichlorobenzyl)-6-(methylsulfanyl)pyridazine
• 英文别名: 3-[(2,4-dichlorophenyl)methyl]-6-methylsulfanylpyridazine
• CAS: 241132-71-8
• 化学式: C₁₂H₁₀Cl₂N₂S
• 分子量: 285.2
• InChiKey: WUMFDUGXIUPYNO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  51.1
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Necroptosis Inhibitors and Methods of Use Therefor
  申请人：Yuan Junying

  公开号：US20140066466A1

  公开（公告）日：2014-03-06

  Described herein are compositions that inhibit the production of TNFα downstream of CD40 activation. As such, also described are various methods of using compositions exhibiting this activity for the treatment or prevention of inflammatory diseases associated with TNFα production or CD40 activation.
• US9643977B2
  申请人：——

  公开号：US9643977B2

  公开（公告）日：2017-05-09
• [EN] NECROPTOSIS INHIBITORS AND METHODS OF USE THEREFOR<br/>[FR] INHIBITEURS DE LA NÉCROPTOSE ET LEURS MÉTHODES D'UTILISATION
  申请人：HARVARD COLLEGE

  公开号：WO2012125544A2

  公开（公告）日：2012-09-20

  Described herein are compositions that inhibit the production of TNFα downstream of CD40 activation. As such, also described are various methods of using compositions exhibiting this activity for the treatment or prevention of inflammatory diseases associated with TNFα production or CD40 activation.