2-Hydroxy-5-[(tetrahydrofuran-2-ylcarbonyl)amino]benzoic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Hydroxy-5-[(tetrahydrofuran-2-ylcarbonyl)amino]benzoic acid
• 英文别名: 2-hydroxy-5-(oxolane-2-carbonylamino)benzoic acid
• 化学式: C₁₂H₁₃NO₅
• 分子量: 251.23
• InChiKey: CXEZAPIJMHHQAM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  95.9
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• REAL-TIME METHOD FOR THE DETECTION OF VIABLE MICRO-ORGANISMS
  申请人：Nederlandse Organisatie voor Toegepast -Natuurwetenschappelijk Onderzoek TNO

  公开号：EP2232243A1

  公开（公告）日：2010-09-29
• US8986946B2
  申请人：——

  公开号：US8986946B2

  公开（公告）日：2015-03-24
• [EN] REAL-TIME METHOD FOR THE DETECTION OF VIABLE MICRO-ORGANISMS<br/>[FR] PROCÉDÉ EN TEMPS RÉEL POUR LA DÉTECTION DE MICRO-ORGANISMES VIABLES
  申请人：TNO

  公开号：WO2009082218A1

  公开（公告）日：2009-07-02

  The invention relates to a method for real-time detection of viable microorganisms comprising: a. addition of a cell-permeable, phototautomeric compound to a micro-organism or other living cell; and b. measuring the fluorescent emission of said phototautomeric compound. Preferably the phototautomeric compound is salicylic acid, 2-hydroxy-l-naphtoic acid or 1- hydroxy-2-naphtoic acid. Further, the assay can be used to assess the antibiotic effect of a test compound. This test can be used as a high- throughput screening for compounds with antibiotic activity. Also part of the invention is the use of a cell permeable phototautomeric compound in a method for determining the viability of micro-organisms and for assessing the antibiotic effect of a test compound.
• [EN] APPARATUS FOR DETECTING VIABLE MICROORGANISMS OR SPORES IN A SAMPLE AND USE THEREOF.<br/>[FR] APPAREIL POUR LA DETECTION DE MICROORGANISMES OU SPORES VIABLES DANS UN ECHANTILLON ET SON UTILISATION
  申请人：TNO

  公开号：WO2010151131A2

  公开（公告）日：2010-12-29

  The present invention relates to the field of microbiology, more particular to an apparatus for detecting viable microorganisms or spores in a sample. Provided is an apparatus comprising an inlet for said sample, a sample immobilization area, a container comprising a composition comprising a phototautomeric compound, a light source and a detection unit. Also provided are the use of such an apparatus for detecting at least one viable microorganism in a sample, and the use of such an apparatus for detecting at least one viable spore in a sample.