4-cyclohexyl-N-(pyridin-4-ylmethyl)benzenesulfonamide | 873588-27-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-cyclohexyl-N-(pyridin-4-ylmethyl)benzenesulfonamide
• CAS: 873588-27-3
• 化学式: C₁₈H₂₂N₂O₂S
• 分子量: 330.4
• InChiKey: HRBIOWBGGRSAGZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  67.4
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] SYSTEMS AND ASSAYS FOR IDENTIFYING PU.1 INHIBITORS<br/>[FR] SYSTÈMES ET ESSAIS POUR IDENTIFIER DES INHIBITEURS DE PU.1
  申请人：MASSACHUSETTS INST TECHNOLOGY

  公开号：WO2021051016A1

  公开（公告）日：2021-03-18

  The disclosure relates to compositions comprising PU.1 inhibitors as well as methods of making and using the same. In some embodiments, methods of screening compounds for PU.1 inhibition are disclosed. In some embodiments, methods of screening a plurality of compounds for PU.1 inhibition are disclosed. In some embodiments, lambda-beta binding (LBB) motifs are used to screen compounds for PU.1 inhibition. In some embodiments, methods of treating neurodegenerative disorders are disclosed. In some embodiments pharmaceutical compounds are provided. In some embodiments, methods of treating Alzheimer's disease, inflammation, or excessive myelin uptake with PU.1 inhibitors are disclosed.