2-[(5-Pyridin-4-yl-1,3,4-oxadiazol-2-yl)sulfanyl]-1-pyrrolidin-1-ylethanone

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 2-[(5-Pyridin-4-yl-1,3,4-oxadiazol-2-yl)sulfanyl]-1-pyrrolidin-1-ylethanone
• 化学式: C₁₃H₁₄N₄O₂S
• 分子量: 290.34
• InChiKey: YITKXNIXWPJFNW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  97.4
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• COMPOUNDS THAT MODULATE NEGATIVE-SENSE, SINGLE-STRANDED RNA VIRUS REPLICATION AND USES THEREOF
  申请人：Shaw Megan L

  公开号：US20110105423A1

  公开（公告）日：2011-05-05

  The present invention relates to compounds that modulate the replication of negative-sense, single-stranded RNA viruses, such as influenza virus, and the use of such compounds. The invention relates to methods for increasing the titer of negative-sense, single-stranded RNA viruses, such as influenza virus, in substrates for virus propagation (e.g., tissue culture). The invention also relates to the use of compounds that decrease virus replication as antiviral agents. The invention further relates to methods for identifying compounds that modulate the replication of negative-sense, single-stranded RNA viruses, in particular, influenza virus.
• Antiviral Compounds and Uses Thereof
  申请人：Shaw Megan

  公开号：US20130137678A1

  公开（公告）日：2013-05-30

  Described herein are Compounds, compositions comprising such Compounds, and the use of such Compounds and compositions as anti-viral agents. In one aspect, provided herein are methods of inhibiting viral replication using Compounds described herein or compositions thereof. In another aspect, provided herein are methods for preventing a symptom of a viral infection using a Compound, or a composition thereof. In another aspect, provided herein are methods of treating and/or managing viral infection using a compound or a composition thereof.
• US8629283B2
  申请人：——

  公开号：US8629283B2

  公开（公告）日：2014-01-14
• US9096585B2
  申请人：——

  公开号：US9096585B2

  公开（公告）日：2015-08-04
• [EN] COMPOUNDS THAT MODULATE NEGATIVE-SENSE, SINGLE-STRANDED RNA VIRUS REPLICATION AND USES THEREOF<br/>[FR] COMPOSÉS QUI MODULENT LA RÉPLICATION DU VIRUS À ARN SIMPLE BRIN, SENS NÉGATIF, ET LEURS UTILISATIONS
  申请人：SINAI SCHOOL MEDICINE

  公开号：WO2009136979A2

  公开（公告）日：2009-11-12

  The present invention relates to compounds that modulate the replication of negative-sense, single-stranded RNA viruses, such as influenza virus, and the use of such compounds. The invention relates to methods for increasing the titer of negative- sense, single-stranded RNA viruses, such as influenza virus, in substrates for virus propagation (e.g., tissue culture). The invention also relates to the use of compounds that decrease virus replication as antiviral agents. The invention further relates to methods for identifying compounds that modulate the replication of negative-sense, single-stranded RNA viruses, in particular, influenza virus.