N-(3-cyano-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)-2-phenylpropionamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(3-cyano-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)-2-phenylpropionamide
• 英文别名: N-(3-Cyano-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)-2-phenyl-propionamide；N-(3-cyano-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)-2-phenylpropanamide
• 化学式: C₁₇H₁₆N₂OS
• 分子量: 296.393
• InChiKey: HSHDZFMMLNJNIA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  81.1
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-苯基丙酸 、 2-氨基-5,6-二氢-4H-环戊烯并噻吩-3-甲腈 在 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 反应 19.0h， 以11%的产率得到N-(3-cyano-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)-2-phenylpropionamide
  参考文献：
  名称：

  Novel substituted 3-cyanothiophene acetamides as glucagon receptor antagonists

  摘要：

  本发明涉及式(I)1的化合物，其中R1、R2、R3、R4和n如描述和索赔中所定义，并且其药学上可接受的盐。这些化合物对于治疗和/或预防与胰高血糖素受体拮抗有关的疾病，如糖尿病，是有用的。

  公开号：

  US20040209943A1

文献信息

• SUBSTITUTED 3-CYANOTHIOPHENE ACETAMIDES AS GLUCAGON RECEPTOR ANTAGONISTS
  申请人：F. HOFFMANN-LA ROCHE AG

  公开号：EP1620425A1

  公开（公告）日：2006-02-01
• Methods For Treating Heart Failure Using Glucagon Receptor Antagonists
  申请人：REMD Biotherapeutics, Inc.

  公开号：US20170143673A1

  公开（公告）日：2017-05-25

  The present invention relates to methods for treating or preventing heart failure using a glucagon receptor antagonist or modulator. In various embodiments, the present invention relates to methods for treating post-myocardial infarction heart failure and lateral ventricular (LV) remodeling. In various embodiments, the present invention relates to methods for treating diabetic cardiomyopathy.
• US7138529B2
  申请人：——

  公开号：US7138529B2

  公开（公告）日：2006-11-21
• [EN] SUBSTITUTED 3-CYANOTHIOPHENE ACETAMIDES AS GLUCAGON RECEPTOR ANTAGONISTS<br/>[FR] ACETAMIDES DE 3-CYANOTHIOPHENE SUBSTITUES EN TANT QU'ANTAGONISTES DE RECEPTEUR DE GLUCAGON
  申请人：HOFFMANN LA ROCHE

  公开号：WO2004092156A1

  公开（公告）日：2004-10-28

  The present invention relates to compounds of formula (I) wherein RI, R2, R3, R4 and n are as defined in the description and claims, and pharmaceutically acceptable salts thereof The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with the antagonism of the glucagon receptor, such as diabetes.
• Novel substituted 3-cyanothiophene acetamides as glucagon receptor antagonists
  申请人：——

  公开号：US20040209943A1

  公开（公告）日：2004-10-21

  The present invention relates to compounds of formula (I) 1 wherein R1, R2, R3, R4 and n are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with the antagonism of the glucagon receptor, such as diabetes.

  本发明涉及式(I)1的化合物，其中R1、R2、R3、R4和n如描述和索赔中所定义，并且其药学上可接受的盐。这些化合物对于治疗和/或预防与胰高血糖素受体拮抗有关的疾病，如糖尿病，是有用的。