9-nitroapomorphine

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 阿朴菲
• 英文名称: 9-nitroapomorphine
• 英文别名: 6-methyl-9-nitro-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol
• 化学式: C₁₇H₁₆N₂O₄
• 分子量: 312.325
• InChiKey: PFOUGROVNHLYIQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.76
• 重原子数：
  23.0
• 可旋转键数：
  1.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  86.84
• 氢给体数：
  2.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  9-nitroapomorphine 在 sodium hydroxide 、 甲脒 作用下， 以 乙醇 为溶剂， 反应 1.0h， 以55%的产率得到9-aminoapomorphine
  参考文献：
  名称：

  Formation of novel thiazolomorphinans and thiazoloaporphines

  摘要：

  A novel strategy has been developed for the synthesis of ring A fused thiazolomorphinans and ring D fused thiazoloaporphines offering the possibility of formation of regioisomeric products. The conventional thermal thiazole-forming reaction was replaced with microwave initiation and a detailed discussion has been presented on the proposed mechanism of the ring Closure. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.08.069
• 作为产物：
  描述：

  2-nitromorphine 在 甲烷磺酸 作用下， 反应 0.42h， 生成 9-nitroapomorphine
  参考文献：
  名称：

  Formation of novel thiazolomorphinans and thiazoloaporphines

  摘要：

  A novel strategy has been developed for the synthesis of ring A fused thiazolomorphinans and ring D fused thiazoloaporphines offering the possibility of formation of regioisomeric products. The conventional thermal thiazole-forming reaction was replaced with microwave initiation and a detailed discussion has been presented on the proposed mechanism of the ring Closure. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.08.069

文献信息

• Formation of novel thiazolomorphinans and thiazoloaporphines
  作者：Levente Girán、Sándor Berényi、Attila Sipos

  DOI：10.1016/j.tet.2008.08.069

  日期：2008.11

  A novel strategy has been developed for the synthesis of ring A fused thiazolomorphinans and ring D fused thiazoloaporphines offering the possibility of formation of regioisomeric products. The conventional thermal thiazole-forming reaction was replaced with microwave initiation and a detailed discussion has been presented on the proposed mechanism of the ring Closure. (C) 2008 Elsevier Ltd. All rights reserved.