1,3-dibenzyl-2-(2-methoxy-phenyl)-imidazolidine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 1,3-dibenzyl-2-(2-methoxy-phenyl)-imidazolidine
• 英文别名: ST036365；1,3-Dibenzyl-2-(2-methoxyphenyl)imidazolidine
• 化学式: C₂₄H₂₆N₂O
• mdl: MFCD01047102
• 分子量: 358.483
• InChiKey: YJEBQKGDMLAINU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  15.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  邻甲氧基苯甲醛 、 N,N'-二苄基乙二胺 以 水 为溶剂， 反应 3.0h， 以94%的产率得到1,3-dibenzyl-2-(2-methoxy-phenyl)-imidazolidine
  参考文献：
  名称：

  Preparation of aminals in water

  摘要：

  Aminals, which are used as protecting groups in syntheses and are part of many biologically active compounds, are normally prepared from aldehydes and diamines under conditions that remove water in order to shift the equilibrium to the side of the aminal. Here we report for the first time that aminals can be prepared and isolated in pure water without a catalyst in high yield and purity. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2004.02.021

文献信息

• Small molecule efflux pump inhibitors
  申请人：UNIVERSITY OF ROCHESTER

  公开号：US10471028B2

  公开（公告）日：2019-11-12

  Small molecule efflux pump inhibitors are provided, as well as methods for their use in treating infections. Also provided herein are methods of using the small molecule efflux pump inhibitors to restore the antibiotic susceptibility of microbes.

  本文提供了小分子外排泵抑制剂及其用于治疗感染的方法。本文还提供了使用小分子外排泵抑制剂恢复微生物抗生素敏感性的方法。
• SMALL MOLECULE EFFLUX PUMP INHIBITORS
  申请人：UNIVERSITY OF ROCHESTER

  公开号：US20170100414A1

  公开（公告）日：2017-04-13

  Small molecule efflux pump inhibitors are provided, as well as methods for their use in treating infections. Also provided herein are methods of using the small molecule efflux pump inhibitors to restore the antibiotic susceptibility of microbes.
• [EN] HEXAHYDROPYRIMIDINE, TETRAHYDRO IMIDAZOLE OR OCTAHYDROAZEPAN DERIVATIVES<br/>[FR] DÉRIVÉS HEXAHYDROPYRIMIDINE, TÉTRAHYDROIMIDAZOLE OU OCTAHYDROAZÉPANE
  申请人：ACTAR AB

  公开号：WO2007139492A1

  公开（公告）日：2007-12-06

  [EN] A compound of formula (I) R2 R3 1 R R4 N N R5 n (I) for use as a medicament. The medicament is suitable for the treatment of conditions such as cancer, keloids and granulomatous skin disorders, psoriasis, pathological neovascularization, excessive hair growth and excessive body weight and for inhibition of stem cell proliferation and induction of differentiation after spinal cord injury and CNS diseases. A method of treat- ing a mammal by administration of a compound of formula (I).
  [FR] La présente invention concerne un composé répondant à la formule (I) R2 R3 1 R R4 N N R5 n (I) destiné à une utilisation comme médicament. Le médicament est approprié pour le traitement d'affections telles que le cancer, des chéloïdes et des troubles granulomateux cutanés, le psoriasis, la néovascularisation pathologique, une pilosité excessive et un poids corporel excessif et pour l'inhibition de la prolifération de cellules souches et l'induction de la différentiation après une lésion médullaire et des troubles du SNC. La présente invention concerne également un procédé de traitement d'un mammifère par l'administration d'un composé répondant à la formule (I).
• Preparation of aminals in water
  作者：Václav Jurčı́k、René Wilhelm

  DOI：10.1016/j.tet.2004.02.021

  日期：2004.3

  Aminals, which are used as protecting groups in syntheses and are part of many biologically active compounds, are normally prepared from aldehydes and diamines under conditions that remove water in order to shift the equilibrium to the side of the aminal. Here we report for the first time that aminals can be prepared and isolated in pure water without a catalyst in high yield and purity. (C) 2004 Elsevier Ltd. All rights reserved.