2,4-dimethyl-pyridine-3,5-dicarboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2,4-dimethyl-pyridine-3,5-dicarboxylic acid
• 英文别名: 2,4-Dimethyl-pyridin-3,5-dicarbonsaeure；2,4-Dimethylpyridine-3,5-dicarboxylic acid
• 化学式: C₉H₉NO₄
• 分子量: 195.175
• InChiKey: RQOKEZYIGCOLNG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  87.5
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2,4-dimethyl-pyridine-3,5-dicarboxylic acid 生成 2,4-二甲基吡啶
  参考文献：
  名称：

  Wolff, Justus Liebigs Annalen der Chemie, 1902, vol. 322, p. 389

  摘要：

  DOI：
• 作为产物：
  描述：

  dimethyl-pyridine-2,3,5-tricarboxylic acid 在 苯酚 作用下， 生成 2,4-dimethyl-pyridine-3,5-dicarboxylic acid
  参考文献：
  名称：

  Koenigs; Mengel, Chemische Berichte, 1904, vol. 37, p. 1330

  摘要：

  DOI：

文献信息

• HIV Integrase Inhibitors
  申请人：Beaulieu Francis

  公开号：US20090253677A1

  公开（公告）日：2009-10-08

  The disclosure generally relates to the novel compounds of formula I, including their salts, which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.

  该披露通常涉及到公式I的新化合物，包括它们的盐，这些化合物抑制HIV整合酶并防止病毒整合到人类DNA中。这种作用使得这些化合物对治疗HIV感染和艾滋病有用。该发明还涵盖了用于治疗HIV感染者的药物组合物和方法。
• [EN] ANIONS AND DERIVED SALTS WITH HIGH DISSOCIATION IN NON-PROTOGENIC SOLVENTS<br/>[FR] ANIONS ET SELS DÉRIVÉS PRÉSENTANT UNE DISSOCIATION ÉLEVÉE DANS DES SOLVANTS NON PROTOGÈNES
  申请人：JONSSON ERLENDUR

  公开号：WO2013072470A1

  公开（公告）日：2013-05-23

  Salts with formula X-M+ wherein M+ is Li, Na, K, an ammonium, a phosphonium, an imidazolium, a pyridinium, or a pyrazolium and X- is an anion formed from covalent linking of two negative moieties to a positive onium-type core are provided. Also provided are electrolytes and batteries produced from these salts.

  提供了具有化学式X-M+的盐，其中M+为Li、Na、K、铵、磷铵、咪唑铵、吡啶铵或吡唑铵，而X-是由两个负基团共价连接到正的铵型核心形成的阴离子。还提供了由这些盐制备的电解质和电池。
• 3,4-Disubstituted, 3,5-disubstituted and 3,4,5-substituted piperidines
  申请人：——

  公开号：US20040034031A1

  公开（公告）日：2004-02-19

  The invention relates to substituted piperidine, piperazine, morpholine and thiomorpholine compounds useful in the treatment of Alzheimer's disease and more specifically to compounds that are capable of inhibiting beta-secretase, an enzyme that cleaves amyloid precursor protein to produce amyloid beta peptide (A-beta), a major component of the amyloid plaques found in the brains of Alzheimer's sufferers.

  本发明涉及替代哌啶、哌嗪、吗啉和硫代吗啉化合物，这些化合物在治疗阿尔茨海默病方面非常有用，更具体地说，这些化合物能够抑制β-分泌酶，这是一种酶，它将淀粉样前体蛋白裂解成淀粉样β肽（A-beta），这是阿尔茨海默病患者大脑中发现的淀粉样斑块的主要成分。
• Pyrrolidine derivative or salt thereof
  申请人：Hachiya Shunichiro

  公开号：US20090062366A1

  公开（公告）日：2009-03-05

  [Problem] To provide a compound which may be used in treating diseases in which a calcium sensing receptor (CaSR) is concerned, particularly hyperparathyroidism. [Means for Resolution] It was found that novel pyrrolidine derivatives which are characterized by the possession of aminomethyl group substituted with arylalkyl group or the like, or salts thereof, have excellent CaSR agonistic regulatory activity and also have excellent selectivity with CYP2D6 inhibitory activity having a possibility of causing drug interaction. Based on the above, these novel pyrrolidine derivatives are useful as therapeutic agents for treating diseases in which CaSR is concerned (hyperparathyroidism, renal osteodystrophy, hypercalcemia and the like).

  [问题] 提供一种可用于治疗钙敏感受体（CaSR）相关疾病，特别是甲状旁腺功能亢进症的化合物。 [解决方法] 发现了一种新型吡咯烷衍生物，其特征在于具有氨甲基基团，该基团被芳基烷基或类似物取代，或其盐，具有出色的CaSR激动调节活性，并且具有出色的选择性与CYP2D6抑制活性，可能导致药物相互作用。基于以上发现，这些新型吡咯烷衍生物可用作治疗CaSR相关疾病（甲状旁腺功能亢进症，肾性骨营养不良，高钙血症等）的治疗剂。
• 1-HYDROXY NAPHTHYRIDINE COMPOUNDS AS ANTI-HIV AGENTS
  申请人：Williams Peter D.

  公开号：US20100056516A1

  公开（公告）日：2010-03-04

  1-Hydroxy naphthyridine compounds (e.g., 1-hydroxy naphthyridin-2(1H)-one compounds of Formula I are inhibitors of HIV integrase and/or HIV RNase H and inhibitors of HIV replication: (I) wherein X and R1-R6 are as defined herein. The compounds are useful in the prophylaxis and treatment of infection by HIV and in the prophylaxis, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other anti-HIV agents such as HIV antivirals, immunomodulators, antibiotics and vaccines.

  1-羟基萘啶化合物（例如，式I中的1-羟基萘啶-2（1H）-酮化合物）是HIV整合酶和/或HIV RNase H的抑制剂，也是HIV复制的抑制剂：（I）其中X和R1-R6如此定义。这些化合物对于预防和治疗HIV感染以及预防、延迟发病和治疗艾滋病非常有用。这些化合物可作为化合物本身或作为药学上可接受的盐的形式用于对抗HIV感染和艾滋病。这些化合物及其盐可作为制药组合物的成分，可以选择与其他抗HIV剂（例如HIV抗病毒药物，免疫调节剂，抗生素和疫苗）组合使用。