(+/-)-3-(2-Naphthyl)-quinuclidine-3-ol

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (+/-)-3-(2-Naphthyl)-quinuclidine-3-ol
• 英文别名: 3-naphthalen-2-yl-1-azabicyclo[2.2.2]octan-3-ol
• 化学式: C₁₇H₁₉NO
• 分子量: 253.344
• InChiKey: RHXKCTIASUYPDT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-奎宁环酮 、 2-溴萘 在 正丁基锂 、 aqueous sodium hydroxide 作用下， 以 乙醚 为溶剂， 生成 (+/-)-3-(2-Naphthyl)-quinuclidine-3-ol
  参考文献：
  名称：

  3-Substituted quinuclidines and their use as nicotinic agonists

  摘要：

  该发明涉及新型的3-取代喹诺啡啶衍生物，发现它们在尼古丁乙酰胆碱受体上是胆碱能配体，并且是单胺受体和转运体的调节剂。由于它们的药理特性，本发明的化合物可能对治疗与中枢神经系统（CNS）的胆碱能系统、外周神经系统（PNS）、平滑肌收缩有关的疾病或紊乱、内分泌疾病或紊乱、神经退行性疾病或紊乱、与炎症有关的疾病或紊乱、疼痛以及因滥用化学物质终止而引起的戒断症状等多种疾病或紊乱具有用处。

  公开号：

  US20040044026A1

文献信息

• 3-substituted quinuclidines and their use as nicotinic agonists
  申请人：Peters Dan

  公开号：US06884807B2

  公开（公告）日：2005-04-26

  This invention relates to novel 3-substituted quinuclidine derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

  本发明涉及新型的3-取代喹诺啡啶衍生物，发现它们是烟碱乙酰胆碱受体的胆碱能配体，并且是单胺受体和转运体的调节剂。由于它们的药理特性，本发明的化合物可能用于治疗与中枢神经系统（CNS）和外周神经系统（PNS）的胆碱能系统有关的疾病或障碍，与平滑肌收缩有关的疾病或障碍，内分泌疾病或障碍，与神经退行性有关的疾病或障碍，与炎症、疼痛以及由滥用化学物质终止引起的戒断症状有关的疾病或障碍。
• 3-SUBSTITUTED QUINUCLIDINES AND THEIR USE AS NICOTINIC AGONISTS
  申请人：NEUROSEARCH A/S

  公开号：EP1339712A1

  公开（公告）日：2003-09-03
• US6884807B2
  申请人：——

  公开号：US6884807B2

  公开（公告）日：2005-04-26
• [EN] 3-SUBSTITUTED QUINUCLIDINES AND THEIR USE AS NICOTINIC AGONISTS<br/>[FR] QUINUCLIDINES SUBSTITUEES EN POSITION 3 ET LEUR UTILISATION EN TANT QU'AGONISTES NICOTINIQUES
  申请人：NEUROSEARCH AS

  公开号：WO2002044176A1

  公开（公告）日：2002-06-06

  This invention relates to novel 3-substituted quinuclidine derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
• 3-Substituted quinuclidines and their use as nicotinic agonists
  申请人：——

  公开号：US20040044026A1

  公开（公告）日：2004-03-04

  This invention relates to novel 3-substituted quinuclidine derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

  该发明涉及新型的3-取代喹诺啡啶衍生物，发现它们在尼古丁乙酰胆碱受体上是胆碱能配体，并且是单胺受体和转运体的调节剂。由于它们的药理特性，本发明的化合物可能对治疗与中枢神经系统（CNS）的胆碱能系统、外周神经系统（PNS）、平滑肌收缩有关的疾病或紊乱、内分泌疾病或紊乱、神经退行性疾病或紊乱、与炎症有关的疾病或紊乱、疼痛以及因滥用化学物质终止而引起的戒断症状等多种疾病或紊乱具有用处。