右旋吗酰胺酒石酸盐 | 2922-44-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 右旋吗酰胺酒石酸盐
• 英文名称: Dextromoramide tartrate
• 英文别名: (2R,3R)-2,3-dihydroxybutanedioic acid;(3S)-3-methyl-4-morpholin-4-yl-2,2-diphenyl-1-pyrrolidin-1-ylbutan-1-one
• CAS: 2922-44-3
• 化学式: C29H38N2O8
• 分子量: 542.6
• InChiKey: ACRMUSVWIFZVSM-JTHHODAVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.44
• 重原子数：
  39
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  148
• 氢给体数：
  4
• 氢受体数：
  9

文献信息

• Directed differentiation of oligodendrocyte precursor cells to a myelinating cell fate
  申请人：The Scripps Research Institute

  公开号：US10660899B2

  公开（公告）日：2020-05-26

  The present invention provides methods of inducing differentiation of oligodendrocyte progenitor cells to a mature myelinating cell fate with a neurotransmitter receptor modulating agent. The present invention also provides methods of stimulating increased myelination in a subject in need thereof by administering said neurotransmitter receptor modulating agent. Methods of treating a subject having a demyelinating disease using a neurotransmitter receptor modulating agent are also provided.

  本发明提供了用神经递质受体调节剂诱导少突胶质祖细胞向成熟髓鞘细胞命运分化的方法。本发明还提供了通过施用所述神经递质受体调节剂刺激有需要的受试者增加髓鞘化的方法。本发明还提供了使用神经递质受体调节剂治疗脱髓鞘疾病的方法。
• Drug-eluting surgical articles with a plurality of geometric elements
  申请人：BioSapien Inc.

  公开号：US10926005B2

  公开（公告）日：2021-02-23

  Disclosed herein is a biomaterial for treating a condition. A biomaterial of the disclosure can be, for example, a surgical article. The biomaterial can comprise a plurality of geometric elements and a therapeutic agent. The biomaterial can comprise a first geometric element formed by a porous border that comprises a polymer and the therapeutic agent. The biomaterial can comprise a second geometric element formed by a non-porous border and a solid region, wherein the therapeutic agent may not diffuse into the second geometric element. Implantation of a biomaterial disclosed herein into a subject can treat, for example, cancer.

  本文公开了一种用于治疗疾病的生物材料。本公开的生物材料可以是外科手术用品等。生物材料可包括多个几何元件和一种治疗剂。生物材料可包括由聚合物和治疗剂组成的多孔边界所形成的第一几何元件。生物材料可包括由无孔边界和固体区域形成的第二几何元件，其中治疗剂可能不会扩散到第二几何元件中。将本文公开的生物材料植入受试者体内可治疗癌症等疾病。
• Chronotherapeutic dosage forms and methods of treatment using chronotherapy
  申请人：——

  公开号：US20030082230A1

  公开（公告）日：2003-05-01

  A chronotherapeutic pharmaceutical formulation comprising a core containing an active agent (e.g., a drug) and a delayed release compression coating comprising a natural or synthetic gum applied onto the surface of the core.

  一种慢性治疗药物制剂，包括含有活性剂（如药物）的核心和涂在核心表面的由天然或合成胶组成的缓释压缩涂层。
• Chronotherapeutic dosage forms
  申请人：Baichwal R. Anand

  公开号：US20050118267A1

  公开（公告）日：2005-06-02

  A chronotherapeutic pharmaceutical formulation comprising a core containing an active agent (e.g., a drug) and a surfactant and a delayed release compression coating comprising a natural or synthetic gum applied onto the surface of the core.

  一种慢性治疗药物制剂，包括含有活性剂（如药物）和表面活性剂的核心，以及涂在核心表面的由天然或合成胶组成的缓释压缩涂层。
• Delayed release dosage forms
  申请人：Baichwal R. Anand

  公开号：US20050112201A1

  公开（公告）日：2005-05-26

  A delayed release pharmaceutical formulation comprising a core containing an active agent (e.g., a drug) and a delayed release compression coating comprising a natural or synthetic gum applied onto the surface of the core.

  一种缓释药物制剂，包括含有活性剂（如药物）的核心和涂在核心表面的由天然或合成胶组成的缓释压缩涂层。