2-(Cyanethoxy)-bis-N,N-(diisopropylamino)phosphane

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-(Cyanethoxy)-bis-N,N-(diisopropylamino)phosphane
• 英文别名: bis(N,N-diisopropylamino)-2-cyanoethoxyphosphine；(2-cyanoethoxy)bis(diisopropylamino)phosphine；bis(diisopropylamino)(2-cyanoethoxy)phosphine；cyanoethoxy-N,N’-diisopropylamine；2-cyanoethoxydiisopropylaminophosphine；N,N-diisopropylchlorophosphoramidite；3-[Di(propan-2-yl)amino]phosphanyloxypropanenitrile
• 化学式: C₉H₁₉N₂OP
• 分子量: 202.236
• InChiKey: YCWVUOFESLTPPC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  13
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  36.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-戊炔-1-醇 、 2-(Cyanethoxy)-bis-N,N-(diisopropylamino)phosphane 在 二异丙基铵盐四氮唑 作用下， 以 二氯甲烷 为溶剂， 反应 5.0h， 以68%的产率得到2-cyanoethyl pent-4-yn-1-yl diisopropylphosphaoramidite
  参考文献：
  名称：

  Azide Solid Support for 3′-Conjugation of Oligonucleotides and Their Circularization by Click Chemistry

  摘要：

  A solid support bearing an azido linker was used to synthesize a 3'-azido-alkyl-oligonucleotide by phosphoramidite chemistry. The resulting oligonucleotide was either conjugated by 1,3-dipolar cycloaddition on solid support or in solution with mannose-propargyl derivative and in solution with dansyl propargyl. Besides, after introduction of an alkyne function at the 5'-end, the resulting oligonucleotide hearing both 3'-azide and 5'-alkyne functions was circularized.

  DOI：

  10.1021/jo9014563

文献信息

• METHOD OF SUPPRESSING FORMATION OF PHOTOCROSSLINK, AND PHOTOREACTIVE NUCLEIC ACID IN WHICH AUTO-CROSSLINK FORMATION IS SUPPRESSED
  申请人：JAPAN SCIENCE AND TECHNOLOGY AGENCY

  公开号：US20160326207A1

  公开（公告）日：2016-11-10

  Provided is a means for preventing the inactivation of a photoresponsive nucleic acid probe by suppressing the formation of a photocrosslink between a photoresponsive base having a photocrosslinkable vinyl structure and a photocrosslinkable thymine (T) or uracil (U) base, by substituting with an R group (R being —CN or —CO—R 1 , where R 1 is a saturated or unsaturated straight-chain or branched cyclic or non-cyclic C1-12 hydrocarbon group) the 5 position of a pyrimidine ring of the thymine (T) or uracil (U) base which is photocrosslinkable with the photoresponsive base having a photocrosslinkable vinyl structure.

  提供了一种防止光响应核酸探针失活的方法，通过在可光交联的含有可光交联乙烯结构的光响应碱基和可光交联胸腺嘧啶（T）或尿嘧啶（U）碱基之间抑制光交联物的形成，通过用R基（R为—CN或—CO—R1，其中R1为饱和或不饱和直链或支链环状或非环状C1-12碳氢化合物基团）替代胸腺嘧啶（T）或尿嘧啶（U）碱基的嘧啶环的5位。
• [EN] CYCLIC DI-NUCLEOTIDE COMPOUNDS AS STING AGONISTS<br/>[FR] COMPOSÉS DI-NUCLÉOTIDIQUES CYCLIQUES UTILISÉS EN TANT QU'AGONISTES DE STING
  申请人：MERCK SHARP & DOHME

  公开号：WO2020117625A1

  公开（公告）日：2020-06-11

  A class of polycyclic compounds of general formula (I), wherein Base1, Base2, Y, Ya, Xa, Xa1, Xb, Xb1, Xc, Xc1, Xd, Xd1, R1, R1a, R2a, R3, R3a, R4, R4a, R5, R6, R6a, R7, R7a, R8, R8a, and R9 are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds. (I)

  提供一类多环化合物，其一般式为（I），其中Base1、Base2、Y、Ya、Xa、Xa1、Xb、Xb1、Xc、Xc1、Xd、Xd1、R1、R1a、R2a、R3、R3a、R4、R4a、R5、R6、R6a、R7、R7a、R8、R8a和R9在此处定义，可能有用作I型干扰素产生的诱导剂，特别是作为STING活性剂。还提供了合成和使用化合物的方法。（I）
• Pentopyranosyl Oligonucleotide Systems. Communication No. 13
  作者：Oliver Jungmann、Markus Beier、Anatol Luther、Hoan K. Huynh、Marc-Olivier Ebert、Bernhard Jaun、Ramanarayanan Krishnamurthy、Albert Eschenmoser

  DOI：10.1002/hlca.200390118

  日期：2003.5

  pentopyranosyl-(4′2′)-oligonucleotide systems derived from D-ribose, D-xylose, L-lyxose, and L-arabinose, the α-arabinopyranosyl system shows by far the strongest WatsonCrick base pairing. The system is, in fact, one of the strongest oligonucleotide-type base-pairing systems known. It undergoes efficient cross-pairing with all the other members of the pentopyranosyl family, but not with RNA and DNA. The

  衍生自D-核糖，D-木糖，L-糖和L-阿拉伯糖的非对映异构戊吡喃糖基-（4'2'）-寡核苷酸系统成员中，α-阿拉伯吡喃糖基系统显示出最强的沃森克里克（Watson Crick）碱基配对。该系统实际上是已知的最强的寡核苷酸型碱基配对系统之一。它与戊吡喃糖基家族的所有其他成员进行有效的交叉配对，但不与RNA和DNA进行交叉配对。该论文描述了α -L-阿拉伯吡喃糖基-（4'2'）-寡核苷酸的合成和性质配对。
• [EN] BICYCLIC NUCLEOSIDES AND OLIGOMERIC COMPOUNDS PREPARED THEREFROM<br/>[FR] NUCLÉOSIDES BICYCLIQUES ET COMPOSÉS OLIGOMÈRES ÉLABORÉS À PARTIR DE CES NUCLÉOSIDES
  申请人：ISIS PHARMACEUTICALS INC

  公开号：WO2011156278A1

  公开（公告）日：2011-12-15

  The present invention provides novel 3', 5 '-linked bicyclic nucleosides and oligomeric compounds prepared therefrom. The bicyclic nucleosides provided herein are useful for enhancing one or more properties of the oligomeric compounds they are incorporated into such as nuclease resistance.

  本发明提供了新颖的3'，5'-连接的双环核苷和由此制备的寡聚化合物。本文提供的双环核苷可用于增强其所结合到的寡聚化合物的一个或多个性质，如核酸酶抗性。
• Nucleotides. Part XXXIX Synthesis of arabinonucleoside phosphoramidite building blocks
  作者：Matthias Resmini、Wolfgang Pfleiderer

  DOI：10.1002/hlca.19930760110

  日期：1993.2.10

  High-yield chemical syntheses of phosphoramidite building blocks of the four arabinonucleosides aUrd (1), aCyd (2), aAdo (3), and aGuo (4), suitable for (3′–5′)oligoarabinonucleotide synthesis are described. The problem of 2′-hydroxy group protection was solved by introduction of the versatile 2-(4-nitrophenyl)ethoxycarbonyl (npeoc) residue, which was also used for aglycon protection.

  描述了适合于（3'-5'）寡阿拉伯糖核苷酸合成的四种阿拉伯核苷aUrd（1），aCyd（2），aAdo（3）和aGuo（4）的亚磷酰胺结构单元的高产率化学合成。通过引入通用的2-（4-硝基苯基）乙氧羰基（npeoc）残基解决了2'-羟基保护的问题，该残基也用于糖苷配基的保护。