(5E)-3-[(2-fluorophenyl)methyl]-5-(1H-indol-3-ylmethylidene)imidazolidine-2,4-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: (5E)-3-[(2-fluorophenyl)methyl]-5-(1H-indol-3-ylmethylidene)imidazolidine-2,4-dione
• 化学式: C₁₉H₁₄FN₃O₂
• 分子量: 335.3
• InChiKey: LKEBYYIMIKDDMS-RQZCQDPDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  65.2
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• [EN] METHODS OF TREATING OR PREVENTING A PROTEOPATHY<br/>[FR] MÉTHODES POUR TRAITER OU PRÉVENIR UNE PROTÉOPATHIE
  申请人：USHER III INITIATIVE INC

  公开号：WO2016201266A1

  公开（公告）日：2016-12-15

  Methods for the treatment or prevention of a proteopathy are described herein.

  本文描述了一种治疗或预防蛋白质病的方法。
• [EN] TREATMENT OF CANCER, INFLAMMATORY DISEASES AND AUTOIMMUNE DISEASES<br/>[FR] TRAITEMENT DU CANCER, DE MALADIES INFLAMMATOIRES ET DE MALADIES AUTO-IMMUNES
  申请人：USHER III INITIATIVE INC

  公开号：WO2022011091A1

  公开（公告）日：2022-01-13

  The present disclosure relates to methods for the treatment or prevention of cancer, an inflammatory disease or an autoimmune disease with compounds of the invention as disclosed herein. The present disclosure also relates to methods for reducing risk of developing cancer, an inflammatory disease or an autoimmune disease with compounds of the invention as disclosed herein.

  本公开涉及使用本文所披露的化合物治疗或预防癌症、炎症性疾病或自身免疫疾病的方法。本公开还涉及使用本文所披露的化合物降低患癌症、炎症性疾病或自身免疫疾病风险的方法。
• [EN] METHODS OF USE FOR OPSIN BINDING LIGANDS<br/>[FR] PROCÉDÉS D'UTILISATION DE LIGANDS DE LIAISON DE L'OPSINE
  申请人：BIKAM PHARMACEUTICALS INC

  公开号：WO2010074746A1

  公开（公告）日：2010-07-01

  Methods of use of compounds of the Formula I1 II, III, IV and/or V are disclosed for treating ophthalmic conditions related to the production of toxic visual cycle products that accumulate in the eye, and are associated with reactions of the visual cycle during medical procedures that expose the eye to light, most commonly the various forms of ophthalmic surgery and stabilize the proper folding of mutant opsins. Compounds and compositions useful in the these methods, either alone or in combination with other therapeutic agents, are also described, along with methods of screening for new agents useful in said treatments.

  公开了利用公式I1 II、III、IV和/或V的化合物治疗与在眼睛中积聚的有毒视觉循环产物有关的眼科疾病的方法，这些产物与暴露于光线的医疗程序期间的视觉循环反应有关，最常见的是各种形式的眼科手术，并稳定突变视蛋白的正确折叠。还描述了在这些方法中有用的化合物和组合物，无论是单独使用还是与其他治疗剂结合使用，以及筛选用于上述治疗的新药物的方法。
• METHODS OF TREATING OR PREVENTING A PROTEOPATHY
  申请人：Usher III Initiative, Inc.

  公开号：US20180099974A1

  公开（公告）日：2018-04-12

  Methods for the treatment or prevention of a proteopathy are described herein.