N-piperidin-1-yl-1-(2,4-dichlorophenyl)-5-phenyl-4,5-dihydro-(1H)-pyrazole-3-carboxamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-piperidin-1-yl-1-(2,4-dichlorophenyl)-5-phenyl-4,5-dihydro-(1H)-pyrazole-3-carboxamide
• 英文别名: Carboxamide derivative 1；2-(2,4-dichlorophenyl)-3-phenyl-N-piperidin-1-yl-3,4-dihydropyrazole-5-carboxamide
• 化学式: C₂₁H₂₂Cl₂N₄O
• 分子量: 417.338
• InChiKey: IAMSOYSVSFMFLR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  47.9
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• 1,3,5-trisubstituted 4,5-dihydro-1H-pyrazole derivatives having CB1-antagonistic activity
  申请人：Lange H.M. Josephus

  公开号：US20050171179A1

  公开（公告）日：2005-08-04

  The present invention relates to 1,3,5-trisubstituted 4,5-dihydro-1H-pyrazole derivatives as CB 1 antagonists, to methods for the preparation of these compounds and to novel intermediates useful for the synthesis of said pyrazole derivatives. The invention also relates to the use of a compound disclosed herein for the manufacture of a medicament giving a beneficial effect. The compounds have the general formula (I) wherein the symbols have the meanings given in the specification.

  本发明涉及1,3,5-三取代的4,5-二氢-1H-吡唑烷衍生物作为CB1受体拮抗剂，以及制备这些化合物的方法和用于合成所述吡唑烷衍生物的新型中间体。该发明还涉及利用本文披露的化合物制造具有益处效果的药物。这些化合物具有一般式(I)，其中符号具有规范中给定的含义。
• 1,3,5-TRISUBSTITUTED 4,5-DIHYDRO-1H-PYRAZOLE DERIVATIVES HAVING CB1-ANTAGONISTIC ACTIVITY
  申请人：Solvay Pharmaceuticals B.V.

  公开号：EP1713475A1

  公开（公告）日：2006-10-25
• US7745476B2
  申请人：——

  公开号：US7745476B2

  公开（公告）日：2010-06-29
• [EN] 1,3,5-TRISUBSTITUTED 4,5-DIHYDRO-1H-PYRAZOLE DERIVATIVES HAVING CB1-ANTAGONISTIC ACTIVITY<br/>[FR] DERIVES DE 4,5-DIHYDRO-1H-PYRAZOLE 1,3,5-TRISUBSTITUES PRESENTANT UNE ACTIVITE ANTAGONISTIQUE A CB1
  申请人：SOLVAY PHARM BV

  公开号：WO2005074920A1

  公开（公告）日：2005-08-18

  The present invention relates to 1,3,5-trisubstituted 4,5-dihydro-1 H-pyrazole derivatives as CB1 antagonists, to methods for the preparation of these compounds and to novel intermediates useful for the synthesis of said pyrazole derivatives. The invention also relates to the use of a compound disclosed herein for the manufacture of a medicament giving a beneficial effect. The compounds have the general formula (I) wherein the symbols have the meanings given in the specification.