bis(2-fluorophenyl) carbonate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: bis(2-fluorophenyl) carbonate
• 化学式: C₁₃H₈F₂O₃
• 分子量: 250.202
• InChiKey: PQFHDQYJJVVZLN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  氯仿 、 2-氟苯酚 在 吡啶 、 氧气 作用下， 反应 1.0h， 以96%的产率得到bis(2-fluorophenyl) carbonate
  参考文献：
  名称：

  与氯仿的按需光碱催化光气化反应：芳基碳酸酯和卤代碳酸酯的合成

  摘要：

  碳酸酯在有机合成中用作 C1 结构单元的溶剂和试剂。该研究报告了一种新型的光按需原位合成碳酸酯与 CHCl 3溶液，其中CHCl 3溶液包含具有相对较高酸度的芳香族或卤代烷基醇和有机碱的混合物。我们发现，CHCl 3溶液中醇和碱的酸碱相互作用在光化学反应中起着关键作用。该反应允许实际合成碳酸二苯酯衍生物、卤代烷基碳酸酯和聚碳酸酯，它们是工业中重要的化学品和材料。

  DOI：

  10.1021/acs.joc.1c01210

文献信息

• [EN] CYCLIC CARBONYL COMPOUNDS WITH PENDANT PENTAFLUOROPHENYL CARBONATE GROUPS, PREPARATIONS THEREOF, AND POLYMERS THEREFROM<br/>[FR] COMPOSÉS CARBONYLÉS CYCLIQUES AVEC GROUPEMENTS PENTAFLUOROPHÉNYLCARBONATE PENDANTS, LEURS SYNTHÈSES ET LEURS POLYMÈRES
  申请人：IBM

  公开号：WO2011135046A1

  公开（公告）日：2011-11-03

  A one pot method of preparing cyclic carbonyl compounds comprising an active pendant pentafluorophenyl carbonate group is disclosed. The cyclic carbonyl compounds can be polymerized by ring opening methods to form ROP polymers comprising repeat units comprising a side chain pentafluorophenyl carbonate group. Using a suitable nucleophile, the pendant pentafluorophenyl carbonate group can be selectively transformed into a variety of other functional groups before or after the ring opening polymerization.

  揭示了一种制备含有活性吊挂五氟苯基碳酸酯基团的环状羰基化合物的一锅法。这些环状羰基化合物可以通过环开启方法聚合，形成包含侧链五氟苯基碳酸酯基团的ROP聚合物重复单元。利用适当的亲核试剂，吊挂的五氟苯基碳酸酯基团可以在环开启聚合之前或之后被选择性地转化为各种其他功能基团。
• NOVEL SELF-REACTIVE ARMS AND PRODRUGS COMPRISING SAME
  申请人：Papot Sebastien

  公开号：US20130144045A1

  公开（公告）日：2013-06-06

  The present invention relates to a compound of general formula (I): in which: X is OH, NH 2 , NHOH or RNH, where R may be a linear or branched, saturated or unsaturated, C1-C10 alkyl radical, Y is H, or an electron-withdrawing group, in particular selected from NO 2 , CF 3 or a halogen, R1 and R2 are H or a linear or branched, saturated or unsaturated, C1-C10 alkyl radical, F is a reactive functional group that can be activated by click chemistry.

  本发明涉及一种通式（I）的化合物： 其中，X为OH，NH2，NHOH或RNH，其中R可能是线性或支链，饱和或不饱和的C1-C10烷基基团， Y为H或电子提取基团，特别是选择自NO2，CF3或卤素， R1和R2为H或线性或支链，饱和或不饱和的C1-C10烷基基团， F是可以通过点击化学激活的反应性功能基团。
• Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
  申请人：Mountain View Pharmaceuticals, Inc.

  公开号：US20040062746A1

  公开（公告）日：2004-04-01

  Methods are provided for the preparation of conjugates of a variety of bioactive components, especially proteins, with water-soluble polymers (e.g., poly(ethylene glycol) and derivatives thereof), which conjugates have reduced antigenicity and immunogenicity compared to similar conjugates prepared using poly(ethylene glycol) containing a methoxyl or another alkoxyl group. The invention also provides conjugates prepared by such methods, compositions comprising such conjugates, kits containing such conjugates or compositions and methods of use of the conjugates and compositions in diagnostic and therapeutic protocols.

  提供了一种制备各种生物活性成分（尤其是蛋白质）与水溶性聚合物（例如聚乙二醇及其衍生物）结合物的方法，这些结合物与使用含有甲氧基或其他烷氧基的聚乙二醇制备的类似结合物相比，具有较低的抗原性和免疫原性。本发明还提供了通过这种方法制备的结合物，包含这种结合物的组合物，包含这种结合物或组合物的工具箱以及在诊断和治疗方案中使用这种结合物和组合物的方法。
• Polymer conjugates of proteinases
  申请人：——

  公开号：US20030012777A1

  公开（公告）日：2003-01-16

  Methods are provided for the stabilization of proteinases by the covalent attachment of or admixture with water-soluble polymers. The resultant stabilized proteinases have increased stability under the harsh conditions used in industrial genomics, which permits their use in the extraction and isolation of nucleic acids and the identification of disease-related prion proteins at elevated temperatures in solutions containing chaotropic agents, such as sodium dodecyl sulfate, urea or guanidinium salts, conferring advantages for robotic applications.

  本研究提供了通过与水溶性聚合物共价连接或混合来稳定蛋白酶的方法。稳定后的蛋白酶在工业基因组学所用的苛刻条件下具有更高的稳定性，可用于提取和分离核酸，以及在含有十二烷基硫酸钠、尿素或胍盐等乱序剂的溶液中在高温下鉴定与疾病相关的朊病毒蛋白，从而为机器人应用带来优势。
• Method for making polycarbonate
  申请人：General Electric Company

  公开号：US20030065129A1

  公开（公告）日：2003-04-03

  Polycarbonates having a high level of endcapping and containing a low level of Fries rearrangement product are prepared from dihydroxy aromatic compounds, such as bisphenol A, and diaryl carbonates such as diphenyl carbonate in a two stage process involving a tetraalkyl phosphonium carboxylate catalyzed oligomerization of the reactants in a first reaction stage followed by the addition of an alkali metal hydroxide co-catalyst in the second stage of the polymerization reaction. The late addition of the co-catalyst provides improved polymerization reaction rates as judged by higher polycarbonate molecular weights. The amount of alkali metal hydroxide co-catalyst is small thus avoiding the formation of excessive amounts of Fries product. The method has been used to provide Fries product levels between 200 and 800 parts per million in polycarbonates having M n values between 7,500 and 8,500 Daltons.

  聚碳酸酯具有较高的端封性，并含有较少的弗里斯重排产物，由双酚 A 等二羟基芳香族化合物和碳酸二芳基酯（如碳酸二苯酯）通过两步法制备而成，其中第一反应阶段采用四烷基鏻羧酸酯催化反应物的低聚物，第二聚合反应阶段加入碱金属氢氧化物助催化剂。根据较高的聚碳酸酯分子量判断，后期添加助催化剂可提高聚合反应速率。碱金属氢氧化物助催化剂的用量很少，因此可避免形成过量的弗里斯产物。该方法可使聚碳酸酯中的 Fries 产物含量介于百万分之 200 至 800 之间，其 M n 值介于 7,500 和 8,500 道尔顿之间的聚碳酸酯中，提供介于百万分之 200 和 800 之间的弗里斯产品。