3-(4-hydroxyphenyl)cyclopentanone

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 3-(4-hydroxyphenyl)cyclopentanone
• 英文别名: 3-(4'-Hydroxyphenyl)-cyclopentanone；3-(4-hydroxyphenyl)cyclopentan-1-one
• 化学式: C₁₁H₁₂O₂
• 分子量: 176.215
• InChiKey: QIPCPQNVFMMVCM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-(4-hydroxyphenyl)cyclopentanone 在 吡啶 、 1,1'-双(二苯膦基)二茂铁二氯化钯(II)二氯甲烷复合物 、 二乙胺基三氟化硫 、 potassium acetate 作用下， 以 1,4-二氧六环 、 二氯甲烷 、 1,2-二氯乙烷 为溶剂， 反应 116.0h， 生成 2-(4-(3,3-difluorocyclopentyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
  参考文献：
  名称：

  [EN] PROCESSES FOR PREPARING TRIAZOLE GLYCOLATE OXIDASE INHIBITORS
  [FR] PROCÉDÉS DE PRÉPARATION D'INHIBITEURS DE GLYCOLATE OXYDASE DE TRIAZOLE

  摘要：

  本公开提供了通过Suzuki偶联反应制备式(I)和(II)的1,2,3-三唑-4-羧酸相关化合物的方法。Suzuki偶联反应是通过将式(IV)化合物，即1,2,3-三唑-4-羧酸酯的硼衍生物，与式(V)的环烷基苯基卤代物或磺酸酯偶联来实现的。

  公开号：

  WO2021142155A1
• 作为产物：
  描述：

  3-(4-(benzyloxy)phenyl)cyclopentan-1-one 生成 3-(4-hydroxyphenyl)cyclopentanone
  参考文献：
  名称：

  METHOD FOR PRODUCING AROMATIC ASTATINE COMPOUND

  摘要：

  This method for producing an aromatic astatine compound comprises reacting an aromatic iodonium ylide with astatine to produce an aromatic astatine compound.

  公开号：

  US20220356205A1

文献信息

• Synthesis and uses of synephrine derivatives
  申请人：Chen Jian

  公开号：US20050250944A1

  公开（公告）日：2005-11-10

  The present invention discloses a novel syntheses of synephrine, its derivatives, and the salts of the foregoing, including their intermediates. One or more of the substituents of the nitrogen atom of the synephrine is/are modified to produce the derivatives. The synephrine derivatives and their salts are useful for treating animals for diseases, conditions, or disorders modulated by β 3 -adrenergic receptor. They are preferably used as fat breakdown agents and/or weight loss agents.

  本发明公开了一种新型合成橙皮碱、其衍生物和上述衍生物的盐，包括它们的中间体。橙皮碱的氮原子的一个或多个取代基被修改以产生衍生物。橙皮碱衍生物及其盐可用于治疗受β3-肾上腺素受体调节的动物的疾病、症状或紊乱。它们通常用作脂肪分解剂和/或减肥剂。
• PHENYL-CYCLOALKYL AND PHENYL-HETEROCYCLIC DERIVATIVES AS S1P RECEPTOR AGONISTS
  申请人：Lynch Kevin R.

  公开号：US20090105315A1

  公开（公告）日：2009-04-23

  Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.

  提供具有在一个或多个S1P受体上拮抗活性的化合物。这些化合物是鞘氨醇类似物，在磷酸化后，可以在S1P受体上表现为激动剂。
• CYCLOALKYLAMINE DERIVATIVES
  申请人：Marumoto Shinji

  公开号：US20120295943A9

  公开（公告）日：2012-11-22

  Provided is a therapeutic agent for hyperparathyroidism, renal osteodystrophy, hypercalcemia and the like, which has a CaSR activating (agonist) action. A compound represented by the following general formula (1): [wherein, Ar which is a partial structure in the general formula (1) represents a phenyl group or a naphthyl group; R 1a and R 1b are the same or different from each other, and represent a hydrogen atom, a halogeno group, or the like; R 2a and R 2b are the same or different from each other, and represent a hydrogen atom, a halogeno group, or the like; A represents a single bond, an oxygen atom, or the like; B represents a single bond, a C1-C4 alkanediyl group, or the like; Z represents a carboxyl group or a tetrazolyl group; and m represents an integer of 1 to 3] or a pharmacologically acceptable salt thereof.

  提供了一种治疗甲状旁腺功能亢进、肾性骨营养不良、高钙血症等疾病的治疗剂，具有CaSR激活（激动剂）作用。该化合物由以下通式（1）表示：[其中，通式（1）中的部分结构Ar表示苯基或萘基；R1a和R1b相同或不同，表示氢原子，卤素基团或类似物；R2a和R2b相同或不同，表示氢原子，卤素基团或类似物；A表示单键，氧原子或类似物；B表示单键，C1-C4烷二基基团或类似物；Z表示羧基或四唑基；m表示1至3的整数]或其药学上可接受的盐。
• NOVEL CYCLIC HYDROCARBON COMPOUNDS FOR THE TREATMENT OF DISEASES
  申请人：Fensholdt Jef

  公开号：US20100317582A1

  公开（公告）日：2010-12-16

  The invention relates to novel cyclic hydrocarbon compounds and derivatives thereof, processes for the preparation thereof, to said compounds for use as a medicament, to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, to methods of treating diseases with said compounds, and to the use of said compounds in the manufacture of medicaments.

  本发明涉及新的环烃化合物及其衍生物，其制备方法，以及将这些化合物用作药物、治疗用化合物、包含这些化合物的药物组合物、使用这些化合物治疗疾病的方法，以及将这些化合物用于药物制造的用途。
• Hydrophobization and silica for supported catalyst
  申请人：Rodriguez George

  公开号：US20050159299A1

  公开（公告）日：2005-07-21

  This invention relates to a catalyst support comprising the result of the combination of: (a) a support comprising hydroxyl groups; (b) a capping agent comprising a boron containing Lewis acid; and (c) an ionic activator, wherein at least some of the capping agent does not form a support bound activator.

  本发明涉及一种催化剂载体，由以下物质组合而成：(a) 由羟基组成的载体；(b) 由含硼的路易斯酸组成的封端剂；以及 (c) 离子活化剂，其中至少部分封端剂不形成与载体结合的活化剂。