1-(3,4-dihydroxy-5-hydroxymethyl-tetrahydrofuran-2-yl)-5-(3,3-dimethylbut-1-ynyl)-1H-pyrimidine-2,4-dione

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: 1-(3,4-dihydroxy-5-hydroxymethyl-tetrahydrofuran-2-yl)-5-(3,3-dimethylbut-1-ynyl)-1H-pyrimidine-2,4-dione
• 英文别名: 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-(3,3-dimethylbut-1-ynyl)pyrimidine-2,4-dione
• 化学式: C₁₅H₂₀N₂O₆
• 分子量: 324.334
• InChiKey: FHKMOCWIZOMDLM-PRULPYPASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  119
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  3,3-二甲基-1-丁炔 、 5-碘尿苷 在 四(三苯基膦)钯 copper(l) iodide 、 三乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 72.0h， 以86%的产率得到1-(3,4-dihydroxy-5-hydroxymethyl-tetrahydrofuran-2-yl)-5-(3,3-dimethylbut-1-ynyl)-1H-pyrimidine-2,4-dione
  参考文献：
  名称：

  Efficient coupling of low boiling point alkynes and 5-iodonucleosides

  摘要：

  The coupling of unprotected 5-iodonucleosides and low boiling point alkynes has been achieved in a high yield for the first time. The coupling is highly dependent on concentration and can be carried out at low temperature and pressure conditions. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.11.047

文献信息

• Efficient coupling of low boiling point alkynes and 5-iodonucleosides
  作者：Stephanos Ghilagaber、William N. Hunter、Rodolfo Marquez

  DOI：10.1016/j.tetlet.2006.11.047

  日期：2007.1

  The coupling of unprotected 5-iodonucleosides and low boiling point alkynes has been achieved in a high yield for the first time. The coupling is highly dependent on concentration and can be carried out at low temperature and pressure conditions. (c) 2006 Elsevier Ltd. All rights reserved.